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  1. Article

    Open Access

    Structural variant evolution after telomere crisis

    Telomere crisis contributes to cancer genome evolution, yet only a subset of cancers display breakage-fusion-bridge (BFB) cycles and chromothripsis, hallmarks of experimental telomere crisis identified in prev...

    Sally M. Dewhurst, **aotong Yao, Joel Rosiene, Huasong Tian… in Nature Communications (2021)

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  2. No Access

    Article

    Pervasive chromosomal instability and karyotype order in tumour evolution

    Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes1,2. The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary ...

    Thomas B. K. Watkins, Emilia L. Lim, Marina Petkovic, Sergi Elizalde… in Nature (2020)

  3. No Access

    Article

    Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

    Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressu...

    Saioa López, Emilia L. Lim, Stuart Horswell, Kerstin Haase… in Nature Genetics (2020)

  4. Article

    Open Access

    Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

    Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to ...

    Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo… in Nature Communications (2017)

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  5. Article

    Correction: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability

    Nature 494, 492–496 (2013); doi:10.1038/nature11935 In this Letter we inadvertently omitted full details of The Cancer Genome Atlas data sets. The Acknowledgements should have included these sentences: “The re...

    Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder, Petra Groth… in Nature (2013)

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  6. No Access

    Article

    Replication stress links structural and numerical cancer chromosomal instability

    A mechanism to explain chromosomal instability (CIN) in colorectal cancer is demonstrated; three new CIN-suppressor genes (PIGN, MEX3C and ZNF516) encoded on chromosome 18q are identified, the loss of which leads...

    Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder, Petra Groth… in Nature (2013)