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Chapter and Conference Paper
Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2?
Oxygen measurements are routinely made either in the vasculature or in the extracellular fluid surrounding the cells of tissues. Yet, metabolic oxygen availability depends on the pO2 within the cells, as does the...
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Chapter and Conference Paper
Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature
The “oxygen paradox” can be explained as two opposing biological processes with oxygen (O2) as a reactant. On the one hand, oxygen is essential to aerobic metabolism, powering oxidative phosphorylation in mitocho...
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Article
Correction to: Atomistic Simulations Modify Interpretation of Spin-Label Oximetry Data. Part 1: Intensified Water–Lipid Interfacial Resistances
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Article
Atomistic Simulations Modify Interpretation of Spin-Label Oximetry Data. Part 1: Intensified Water–Lipid Interfacial Resistances
The role of membrane cholesterol in cellular function and dysfunction has been the subject of much inquiry. A few studies have suggested that cholesterol may slow oxygen diffusive transport, altering membrane ...
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Chapter
Discerning Membrane Steady-State Oxygen Flux by Monte Carlo Markov Chain Modeling
Molecular oxygen (O2) permeability coefficients for lipid bilayers have previously been estimated using both electron paramagnetic resonance (EPR) oximetry and molecular dynamics simulation data. Yet, neither tec...
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Chapter
Simulation Study of Breast Cancer Lipid Changes Affecting Membrane Oxygen Permeability: Effects of Chain Length and Cholesterol
Tumor radiotherapy relies on intracellular oxygen (O2) to generate reactive species that trigger cell death, yet hypoxia is common in cancers of the breast. De novo lipid synthesis in tumors supports cell prolife...
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Chapter
Updated Evaluation of Cholesterol’s Influence on Membrane Oxygen Permeability
There is a surprising gap in knowledge regarding the mechanism of oxygen (O2) diffusional delivery at the level of tissues and cells. Yet, the effectiveness of tumor radiotherapy, the success of tissue engineerin...
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Book
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Chapter
Pathways of Oxygen Diffusion in Cells and Tissues
Oxygen delivery to tissue mitochondria relies on simple diffusion in the target cells and tissues. As such, intracellular availability of O2 in tissue depends on its solubility and diffusivity in complex and hete...
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Chapter
Reduced Oxygen Permeability upon Protein Incorporation Within Phospholipid Bilayers
Intracellular oxygenation is key to energy metabolism as well as tumor radiation therapy. Although integral proteins are ubiquitous in membranes, few studies have considered their effects on molecular oxygen p...
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Chapter
Predicted Decrease in Membrane Oxygen Permeability with Addition of Cholesterol
Aberrations in cholesterol homeostasis are associated with several diseases that can be linked to changes in cellular oxygen usage. Prior biological and physical studies have suggested that membrane cholestero...
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Chapter and Conference Paper
Magnification of Cholesterol-Induced Membrane Resistance on the Tissue Level: Implications for Hypoxia
High cellular membrane cholesterol is known to generate membrane resistance and reduce oxygen (O2) permeability. As such, cholesterol may contribute to the Warburg effect in tumor cells by stimulating intracellul...
