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  1. No Access

    Article

    Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas

    Adult-type diffuse gliomas are divided into Astrocytoma, IDH-mutant, Oligodendroglioma, IDH-mutant and 1p/19q-codeleted and Glioblastoma, IDH-wildtype based on the IDH mutation, and 1p/19q codeletion status. T...

    Tomohide Nishikawa, Fumiharu Ohka, Kosuke Aoki, Hiromichi Suzuki… in Brain Tumor Pathology (2023)

  2. No Access

    Article

    Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas

    Since the World Health Organization 2016 classification (2016 WHO), genetic status has been incorporated into the diagnosis of Grade 2/3 gliomas (lower-grade gliomas). Therefore, immunohistochemistry (IHC) of ...

    Tomohide Nishikawa, Reiko Watanabe, Yotaro Kitano, Akane Yamamichi… in Brain Tumor Pathology (2022)

  3. No Access

    Article

    Genetic analysis in patients with newly diagnosed glioblastomas treated with interferon-beta plus temozolomide in comparison with temozolomide alone

    This study aimed to explore the genetic alterations and to identify good responders in the experimental arm in the tumor samples from newly diagnosed glioblastoma (GBM) patients enrolled in JCOG0911; a randomi...

    Atsushi Natsume, Kosuke Aoki, Fumiharu Ohka, Sachi Maeda… in Journal of Neuro-Oncology (2020)

  4. No Access

    Article

    Malignant transformation of a dysembryoplastic neuroepithelial tumor verified by a shared copy number gain of the tyrosine kinase domain of FGFR1

    Dysembryoplastic neuroepithelial tumors (DNTs) are regarded as benign glioneuronal neoplasms because of their excellent outcomes; however, rare DNTs show malignant transformation. We herein described a case of...

    Nozomi Matsumura, Atsushi Natsume, Sachi Maeda, Kosuke Aoki… in Brain Tumor Pathology (2020)

  5. No Access

    Article

    Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion

    The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry ...

    Akane Yamamichi, Fumiharu Ohka, Kosuke Aoki, Hiromichi Suzuki… in Brain Tumor Pathology (2018)

  6. No Access

    Article

    A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR

    Detection of mutations in the isocitrate dehydrogenase 1 (IDH1) gene is useful for accurate diagnosis of lower grade gliomas, as described in the 2016 World Health Organization classification of tumors of the cen...

    Masaki Hirano, Fumiharu Ohka, Sachi Maeda, Lushun Chalise… in Brain Tumor Pathology (2018)