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  1. No Access

    Article

    Optimized polyethylenimine (PEI)-based nanoparticles for siRNA delivery, analyzed in vitro and in an ex vivo tumor tissue slice culture model

    The non-viral delivery of small RNA molecules like siRNAs still poses a major bottleneck for their successful application in vivo. This is particularly true with regard to crossing physiological barriers upon ...

    Alexander Ewe, Sabrina Höbel, Claudia Heine… in Drug Delivery and Translational Research (2017)

  2. No Access

    Protocol

    Polymer-Based Delivery of RNA-Based Therapeutics in Ovarian Cancer

    RNA interference (RNAi) is a naturally occurring, powerful mechanism for gene silencing, based on the cleavage of a given target mRNA. It relies on small interfering RNAs (siRNAs) in the cell. Being similar in...

    Ulrike Weirauch, Daniela Gutsch, Sabrina Höbel, Achim Aigner in Ovarian Cancer (2013)

  3. Article

    Open Access

    Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma

    Fibroblast growth factors FGF-1 and FGF-2 are often upregulated in tumors, but tightly bound to heparan sulphate proteoglycans of the extracellular matrix (ECM). One mechanism of their bioactivation relies on ...

    Daniel Schulze, Philipp Plohmann, Sabrina Höbel, Achim Aigner in Molecular Cancer (2011)

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    Protocol

    Polyethylenimine (PEI)/siRNA-Mediated Gene Knockdown In Vitro and In Vivo

    Since its discovery about 10 years ago, RNA interference (RNAi) has become an almost standard method for the knockdown of any target gene of interest. It is mediated by small interfering RNAs (siRNAs), which t...

    Sabrina Höbel, Achim Aigner in RNA Interference (2010)