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  1. Article

    Open Access

    The Impact of Mandatory Reporting of Non-Serious Safety Reports to EudraVigilance on the Detection of Adverse Reactions

    European Union legislation has mandated the submission of European Economic Area non-serious reports to the EudraVigilance database since November 2017. As spontaneous reports of suspected adverse reactions to...

    Gianmario Candore, Sebastian Monzon, Jim Slattery, Loris Piccolo… in Drug Safety (2022)

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    Article

    Comparison of the in vitro binding characteristics of the β-carbolines harman and norharman in rat brain and liver and in bovine adrenal medulla

    The in vitro binding of the naturally occurring β-carbolines harman and norharman in their tritium-labelled forms to cell membranes from the rat brain and liver and from bovine adrenal medulla was investigated...

    Torsten May, Alexa Greube, Sabine Strauss… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1994)

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    Article

    Neuroleptics andβ-carbolines displace (3H)imipramine from its binding sites in human and rat tissues

    Most investigations dealing with the pharmacological characterization of (3H)imipramine binding sites focus on tricyclic antidepressants (TCA). This approach seemed to be justified since imipramine belongs to tha...

    H. Rommelspacher, Sabine Strauss in Journal of Neural Transmission (1985)

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    Article

    Pharmacokinetics of tetrahydronorharmane (tetrahydro-β-carboline) in rats

    The distribution, metabolism and elimination into the urine of (14C)-tetrahydronorharmane (THN) as well as of (14C)-6-hydroxy-tetrahydronorharmane (6-OH-THN) are investigated in female and male rats. Following in...

    Barbara Greiner, Christa Fähndrich… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1983)

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    Article

    Effect of lesions of raphe nuclei on the activity of catecholaminergic and serotonergic neurones in various brain regions of the ratin vivo

    The dorsal raphe nucleus (DRN), the median raphe nucleus (MRN) and the B9 cell groups were lesioned separately. Then, the concentrations of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopa...

    H. Rommelspacher, Sabine Strauss in Journal of Neural Transmission (1980)

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    Article

    Inhibition of 5-hydroxytryptamine uptake by tetrahydronorharmane in vivo

    Injection of tetrahydronorharmane (THN) elicited a dose-dependent increase of the level of 5-hydroxytryptamine (5-HT) and a fall of 5-hydroxyindoleacetic acid in the rat brain whereas noradrenaline and dopamin...

    Hans Rommelspacher, Sabine Strauss… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1978)

  7. No Access

    Article

    N-acetyltransferase activity in pineal gland of rats treated with pargyline

    After injection of 20 mg/kg of the monoamine oxidase inhibitor pargyline every other day up to 9 days, the activity of N-acetyltransferase (NAT) in the pineal gland of rats remained unchanged during the light-...

    Petra Bade, Hans Rommelspacher… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1977)