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Article
Open AccessSupervised machine learning enables non-invasive lesion characterization in primary prostate cancer with [68Ga]Ga-PSMA-11 PET/MRI
Risk classification of primary prostate cancer in clinical routine is mainly based on prostate-specific antigen (PSA) levels, Gleason scores from biopsy samples, and tumor-nodes-metastasis (TNM) staging. This ...
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Article
Biopsietechniken im oberen Harntrakt zur Diagnostik des Urothelkarzinoms: systematische Übersicht
Die diagnostische Genauigkeit von Biopsien des oberen Harntraktes ist durch technische Schwierigkeiten bei der Entnahme und die geringe Größe der Präparate limitiert.
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Article
Concomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomy
Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival. We aimed to evaluate whether the detection of carcinoma in situ (CIS) at the t...
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Article
Predictors of oncological outcomes in T1G3 patients treated with BCG who undergo radical cystectomy
To evaluate the oncological impact of postponing radical cystectomy (RC) to allow further conservative therapies prior to progression in a large multicentre retrospective cohort of T1-HG/G3 patients initially ...
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Article
Recurrence, progression and cancer-specific mortality according to stage at re-TUR in T1G3 bladder cancer patients treated with BCG: not as bad as previously thought
The goals of transurethral resection of a bladder tumor (TUR) are to completely resect the lesions and to make a correct diagnosis to adequately stage and treat the patient. Persistent disease after TUR is not...
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Article
Open Access68Ga-PSMA 11 ligand PET imaging in patients with biochemical recurrence after radical prostatectomy – diagnostic performance and impact on therapeutic decision-making
To evaluate the diagnostic performance of [68Ga]Ga-PSMAHBED-CC conjugate 11 positron emission tomography (PSMA-PET) in the early detection of metastases in patients with biochemical recurrence (BCR) after radical...
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Article
Prognostic significance of Fuhrman grade and age for cancer-specific and overall survival in patients with papillary renal cell carcinoma: results of an international multi-institutional study on 2189 patients
Because the prognostic impact of the clinical and pathological features on cancer-specific survival (CSS) and overall survival (OS) in patients with papillary renal cell carcinoma (papRCC) is still controversi...
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Article
Prognostic value of the new Grade Groups in Prostate Cancer: a multi-institutional European validation study
We aimed to assess the prognostic relevance of the new Grade Groups in Prostate Cancer (PCa) within a large cohort of European men treated with radical prostatectomy (RP).
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Article
Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract
This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC).
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Article
The impact of local treatment of the primary tumor site in node positive and metastatic prostate cancer patients
Surgical treatment of the primary tumor in patients with metastatic prostate cancer (mPCa) is gaining traction. We discuss the biological rational and the existing literature on this approach.
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Article
The prognostic role of preoperative serum C-reactive protein in predicting the biochemical recurrence in patients treated with radical prostatectomy
To assess the prognostic value of preoperative C-reactive protein (CRP) serum levels for prognostication of biochemical recurrence (BCR) after radical prostatectomy (RP) in a large multi-institutional cohort.
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Article
Non-surgically related causes of erectile dysfunction after bilateral nerve-sparing radical prostatectomy
Erectile dysfunction (ED) represents one of the most common long-term side effects in prostate cancer (PCa) patients treated with bilateral nerve-sparing radical prostatectomy (BNSRP). The aim of our study was...
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Article
Determinants of long-term survival of patients with locally advanced prostate cancer: the role of extensive pelvic lymph node dissection
The therapeutic effect of pelvic lymph node dissection (PLND) during radical prostatectomy (RP) due to prostate cancer (PCa) is still under debate. We aimed at assessing the impact of more extensive PLND on ca...
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Article
Open AccessPretherapeutic gamma-glutamyltransferase is an independent prognostic factor for patients with renal cell carcinoma
Gamma-glutamyltransferase (GGT) regulates apoptotic balance and promotes cancer progression and invasion. Higher pretherapeutic GGT serum levels have been associated with worse outcomes in various malignancies...
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Article
Open AccessClinical nodal staging scores for prostate cancer: a proposal for preoperative risk assessment
Pelvic lymph node dissection in patients undergoing radical prostatectomy for clinically localised prostate cancer is not without morbidity and its therapeutical benefit is still a matter of debate. The object...
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Article
Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy
The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.
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Article
Open AccessAccuracy of the EORTC risk tables and of the CUETO scoring model to predict outcomes in non-muscle-invasive urothelial carcinoma of the bladder
The European Organization for Research and Treatment of Cancer (EORTC) risk tables and the Spanish Urological Club for Oncological Treatment (CUETO) scoring model are the two best-established predictive tools ...
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Article
Kaplan-Meier-Analysen in der urologischen Praxis
Kaplan-Meier-Kurven und Überlebensschätzungen sind gängige Methoden Überlebensdaten in der Medizin zu präsentieren, insbesondere wenn das Follow-up der Studienteilnehmer unterschiedliche Längen besitzt. Unabhä...
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Article
Verwendung und Bedeutung der „number needed to treat“ in der urologischen Praxis
Die „number needed to treat“ (NNT) ist für den Kliniker eine einfache Methode zur Beurteilung sowohl des Nutzens als auch des Kostens einer Therapie. Essentiell für eine richtige Interpretation der NNT ist die...
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Article
Konfidenzintervalle und p-Werte in der Urologie
P-Werte und Konfidenzintervalle (KI) sind gängige Hilfsmittel, um Ergebnisse in der urologischen Literatur zu beschreiben. Dennoch sind zahlreiche Leser, Autoren und Reviewer wenig mit der Interpretation diese...
