4 Result(s)

Article

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence

Werner syndrome (WS) results from dysfunction of the WRN protein, and is associated with premature aging and early death. Here we report that loss of WRN function elicits accumulation of the Yes-associated pro...

F Fausti, S Di Agostino, M Cioce, P Bielli, C Sette… in Cell Death & Differentiation (2013)

Article

miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer

Micro RNAs (miRs) are small non-coding RNAs aberrantly expressed in human tumors. Here, we aim to identify miRs whose deregulated expression leads to the activation of oncogenic pathways in human gastric cance...

A Sacconi, F Biagioni, V Canu, F Mori, A Di Benedetto, L Lorenzon… in Cell Death & Disease (2012)

Article

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

p53 mutations have profound effects on non-small-cell lung cancer (NSCLC) resistance to chemotherapeutic treatments. Mutant p53 proteins are usually expressed at high levels in tumors, where they exert oncogen...

S Donzelli, G Fontemaggi, F Fazi, S Di Agostino, F Padula… in Cell Death & Differentiation (2012)

Article

The Hippo tumor suppressor pathway: a report on ‘the second workshop on the Hippo tumor suppressor pathway’

H McNeill, M Sudol, G Halder, S Strano, G Blandino, Y Shaul in Cell Death & Differentiation (2011)