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  1. No Access

    Article

    Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells

    Hs578T human breast cancer cells are an oestrogen receptor (ER)-negative cell line. Treatment of these cells with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in formation of a 6.9 S nuclear aryl hydroc...

    WL Wang, JS Thomsen, W Porter, M Moore, S Safe in British Journal of Cancer (1996)

  2. No Access

    Chapter and Conference Paper

    Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression

    2,3,7,8- Tetr achlorodibenzo-p-dioxin (TCDD) and related compounds elicit diverse toxic and biochemical responses in laboratory animals and mammalian cells in culture. TCDD induces CYP1A1 gene expression and resu...

    S. Safe, V. Krishnan in Toxicology in Transition (1995)

  3. No Access

    Article

    Effects of individual terphenyls and polychlorinated terphenyls on rat hepatic microsomal cytochrome P-450-dependent monooxygenases: structure-activity relationships

    The effects of o-, m- and p-terphenyl, 2,4-dichloro-, 2,4,6-trichloro-, 2,3,5,6-tetrachloro-, 2,3,4,6-tetrachloro-, 2,4,4'",6- tetrachloro- and 2,3,4,5-tetrachloro-p-terphenyl, 2,3,4,5-tetrachloro-m- and o-terphe...

    B. D. Leece, M. A. Denomme, S. M. A. Li, R. A. Towner… in Archives of Toxicology (1986)

  4. No Access

    Article

    Detection of the ergosterol and episterol isomers lichesterol and fecosterol in nystatin-resistant mutants of Neurospora crassa

    Wild-type Neurospora crassa is completely inhibited by 5 ppm nystatin. Ultraviolet-induced mutants have been isolated that grow in the presence of 60 ppm of the antibiotic. Gas-liquid chromatographic, mass spectr...

    D. C. Morris, S. Safe, R. E. Subden in Biochemical Genetics (1974)