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Article
Brain catalase in the streptozotocin-rat model of sporadic Alzheimer’s disease treated with the iron chelator–monoamine oxidase inhibitor, M30
Low intracerebroventricular (icv) doses of streptozotocin (STZ) produce regionally specific brain neurochemical changes in rats that are similar to those found in the brain of patients with sporadic Alzheimer’...
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Article
The copper chelator, D-penicillamine, does not attenuate MPTP induced dopamine depletion in mice
In MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and 6-hydroxydopamine induced dopaminergic neurotoxicity and Parkinson’s disease iron accumulates in substantia nigra pars compacta which has been suggest...
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Reference Work Entry In depth
Gene and Protein Expression Profiling in Parkinson's Disease: Quest for Neuroprotective Drugs
In spite of the extensive studies performed on postmortem substantia nigra (SN) of Parkinson's disease (PD) brains, the etiology of the disease has not yet been established. The identification of single mutate...
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Chapter and Conference Paper
Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety
Our recent studies aimed to elucidate the molecular and biochemical mechanism of actions of the novel anti-Parkinson’s drug, rasagiline, an irreversible and selective monoamine oxidase (MAO)-B inhibitor and it...
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Article
Genome-wide linkage scans for prediabetes phenotypes in response to 20 weeks of endurance exercise training in non-diabetic whites and blacks: the HERITAGE Family Study
Impaired insulin secretion, insulin action, insulin-independent glucose effectiveness, glucose tolerance and the associated abnormalities in insulin and glucose metabolism phenotypes are precursors of type 2 d...
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Article
Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes
Gene expression profiling of human substantia nigra pars compacta (SNpc) from Parkinson’s disease (PD) patients, was examined employing high density microarrays. We identified alterations in the expression of ...
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Article
Inclusion body myositis in connective tissue disorders: case report and review of the literature
We report a patient with systemic lupus erythematosus (SLE) and secondary Sjögren’s syndrome (SS) who developed inclusion body myositis (IBM) which, contrary to the typical presentation of this disorder, was s...
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Article
The use of laparoscopy in abdominal emergencies
Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and Novem...
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Chapter
Rapid Leaching Procedures — Possibilities and Limits
On-site investigations are expected to give fast information on the hazardous potential of soil or landfill material. While most of the common field analytical methods will measure the total contamination a so...
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Article
MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson’s disease: neuroprotective strategies
The etiology of Parkinson’s disease is not known. Nevertheless, a significant body of biochemical data from human brain autopsy studies and from animal models points to an ongoing process of oxidative stress...
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Chapter and Conference Paper
cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson’s disease
cDNA microarray membranes comprising 1,200 different gene fragments have been employed to identify gene expression profile in MPTPinduced nigro striatal dopamine neurodegeneration and its protection with R-apo...
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Chapter and Conference Paper
Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphine
There have been many attempts to discover neuroprotective drugs for the treatment of Parkinson’s disease (PD). Many ofthese compounds either do not cross the blood brain barrier or are not very effective in th...
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Chapter and Conference Paper
Potent neuroprotective and antioxidant activity of apomorphine in MPTP and 6-hydroxydopamine induced neurotoxicity
Apomorphine is a potent radical scavenger and iron chelator. In vitro apomorphine acts as a potent iron chelator and radical scavenger with IC50 of 0.3 μM for iron (2.5 μM) induced lipid peroxidation in rat brain...
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Article
ACTIVATING MUTATION IN THE STIMULATORY G PROTEIN GENE IN AN INFANT WITH ADRFNOCORTICONODULAR DYSPLASIA
Infantile Cushing's Syndrome is a rare condition caused by excess cortisol production. We describe an activating mutation in the gene coding for the stimulatory G protein (Gsalpha) in DNA from adrenal tissue in a...
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Article
DIMINISHED TSH SECRETION ASSOCIATED WITH NEONATAL THYROTOXICOSIS
We report 3 1/2 year old twin boys with prolonged neonatal thyrotoxicosis and persistently low TSH secretion manifested by a diminished TSH response to hypothyroxinemia and to TRH stimulation. Features of neon...
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Chapter
Hydrology of Arid Zones
The term water crop denotes the resources of liquid water (surface water as well as groundwater) that are generated by precipitation at more or less regular intervals. The part of the hydrologic cycle that genera...
