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Article
Assessment of the functional impact of germline BRCA1/2 variants located in non-coding regions in families with breast and/or ovarian cancer predisposition
The molecular mechanism of breast and/or ovarian cancer susceptibility remains unclear in the majority of patients. While germline mutations in the regulatory non-coding regions of BRCA1 and BRCA2 genes have been...
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Article
DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia
We investigated the prognostic impact of minimal residual disease (MRD) monitoring in acute myeloid leukemia patients harboring DNA methyltransferase 3A-R882H/-R882C mutations (DNMT3Amut). MRD was determined by r...
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Article
BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells
Myeloproliferative neoplasms with myelofibrosis (MPN-MF) demonstrate constitutive activation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling that responds to treatment wit...
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Article
Preoperative anemia is associated with adverse outcome in patients with urothelial carcinoma of the bladder following radical cystectomy
Radical cystectomy (RC) can be associated with significant blood loss, whereas many patients are presenting with anemia preoperatively. To date, there is a lack of data addressing the impact of preoperative an...
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Article
Open AccessFulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex
Breast cancer is the leading cause of cancer death in women living in the western hemisphere. Despite major advances in first-line endocrine therapy of advanced oestrogen receptor (ER)-positive breast cancer, ...
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Article
Open AccessBay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion
Many cancers spread through lymphatic routes, and mechanistic insights of tumour intravasation into the lymphatic vasculature and targets for intervention are limited. The major emphasis of research focuses cu...
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Article
Open AccessIn vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen
As metastasis is the prime cause of death from malignancies, there is vibrant interest to discover options for the management of the different mechanistic steps of tumour spreading. Some approved pharmaceutica...
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Article
Open AccessNF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells
The intravasation of breast cancer into the lymphendothelium is an early step of metastasis. Little is known about the mechanisms of bulky cancer invasion into lymph ducts.
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Article
Traumaversorgung – eine globale Herausforderung
Interne Fixierung von Frakturen ist eine essentielle Komponente der Gesundheitsversorgung. Allerdings ist dies ein Privileg der entwickelten Staaten. Insbesondere für die humanitäre Hilfe in den sog. Entwicklu...
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Article
Unfallchirurgische Katastrophenhilfe nach dem Erdbeben in Haiti 2010 - Ein Erfahrungsbericht
Das Erdbeben in Haiti im Januar 2010 verursachte über 220.000 Tote und mehr als 300.000 Verletzte. Damit stellt es einen der größten Massenanfälle von Verletzten in der jüngeren Geschichte dar. „Ärzte ohne Gre...
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Article
Erratum: Subcellular localisation of Cdc25A determines cell fate
Correction to: Cell Death and Differentiation advanced online publication 5 September 2003; doi:10.1038/sj.cdd.4401318 Since the advanced online publication, the authors have identified an error. The spelling ...
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Article
Subcellular localisation of Cdc25A determines cell fate
Cell division cycle 25A (Cdc25A) was shown to colocalise both with nuclear and cytoplasmic proteins. Recently, we have demonstrated that overexpressed Cdc25A promoted the survival of rat 423 cells through indi...
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Article
Expression of the two alternative [a] and [b] transcripts of CCND1 gene in cyclin D1-expressing B-malignancies: relevance for the pathogenesis
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Article
Water-borne acrylic dispersions for industrial wood coatings
Water-based binders, which make it possible to formulate low-solvent coatings for wood in industrial coating processes, are attracting more and more attention in the light of changing legislation (eg in Europe...
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Chapter
Enzephalopathien bei erworbenen metabolischen Erkrankungen
Neurologische Symptome bei erworbenen metabolischen Störungen sind selten charakteristisch und setzen daher das Verständnis pathophysiologischer Zusammenhänge voraus. Die hypothesengesteuerte Differentialdiagn...
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Chapter and Conference Paper
Labyrinthaufgaben bei schizophrenen Patienten: Interaktionen von Perzeption und Handlung
Seit Kraepelins (1899) Neudefinition der Dementia Praecox ist das Vorliegen kognitiver Störungen ein entscheidendes Kriterium für die Diagnose schizophrener Erkrankungen. Probleme der Aufmerksamkeit, bei der S...
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Chapter and Conference Paper
Film formation of latex dispersions observed with evanescent dynamic light scattering
We have applied evanescent dynamic light scattering (DLS) to study the film formation of polymer latex dispersions. A dynamical glass transition is observed. When the particles fuse, the scattering rate decrea...
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Article
Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein
The identification of germline mutations in a large number of clinically well-characterised patients with familial adenomatous polyposis (FAP) has allowed the unravelling of several genotype-phenotype relation...
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Article
Some considerations on estimating event-related brain signals
Understanding the timing of mental acts is one of the prominent questions in information processing research. The analysis of event related potentials (ERP) with their high temporal resolution might make acces...
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Article
Interleukin-6 serum levels in healthy persons correspond to the sleep-wake cycle
