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  1. No Access

    Chapter

    Introduction to the Study and Role of Background Current Mechanisms in the Heart

    The concept of background current mechanisms has a very long history since the passive permeability of excitable cells was studied well before the active gated conductances were discovered. One of the earliest...

    D. Noble, S. J. Noble, T. Kiyosue… in Ionic Channels and Effect of Taurine on th… (1993)

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    Article

    Inbreeding effects in captive populations of ruffed lemurs

    The two subspecies of ruffed lemurs (Vareica variegata variegata andVarecia variegata rubra) have been maintained in captivity since 1959 and all institutions which hold ruffed lemurs have contributed data to the

    S. J. Noble, R. K. Chesser, O. A. Ryder in Human Evolution (1990)

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    Article

    An isoprenaline activated sodium-dependent inward current in ventricular myocytes

    In the heart, catecholamines affect pacemaker activity by shifting the activation curve for the nonspecific inward current1–4 and increasing both the calcium current5–8, and the delayed potassium current9. We rep...

    T. M. Egan, D. Noble, S. J. Noble, T. Powell, V. W. Twist in Nature (1987)

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    Article

    How does adrenaline accelerate the heart?

    THE way in which adrenaline acts on the sinoatrial (SA) node to accelerate the heart rate has hitherto been obscure. However, in various other parts of the heart adrenaline increases the slow inward (Ca2+/Na+) cu...

    H. F. BROWN, D. DIFRANCESCO, S. J. NOBLE in Nature (1979)