Skip to main content

4 Result(s)

within S. J. Gadd Remove this filter Immunology Remove this filter Pharmacology/Toxicology Remove this filter

and

  1. No Access

    Article

    Conditional pharmacology: II. Ambivalent effects of aurocyanide, a putative active metabolite of anti-arthritic gold drugs, on human and rat PMN leucocytes

    Aurocyanide, and to a lesser extent, aurothiomalate and aurothiosulphate, showed diverse antioxidant/pro-oxidant effects on PMN leucocytes when stimulated ex-vivo to generate hydrogen peroxide. In normal human...

    S. J. Gadd, M. W. Whitehouse, B. Vernon-Roberts in InflammoPharmacology (1992)

  2. No Access

    Article

    Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites

    Aspirin and salicylate are transformed by stimulated human polymorphonuclear leucocytes (PMN), likely to be found at inflammatory sites, into both 2,3- and 2,5-dihydroxybenzoates (DHB). These DHB inhibit both ...

    D. R. Haynes, P. F. A. Wright, S. J. Gadd, M. W. Whitehouse… in Agents and Actions (1993)

  3. No Access

    Article

    Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: The regulation of lymph node cell populations and cytokine production

    A single dose of either cyclosporin-A (CsA) or lobenzarit (CCA) given with an arthrogenic adjuvant completely prevented expression of experimental adjuvant arthritis in rats. The aim of this study was to under...

    D. R. Haynes, S. J. Gadd, M. W. Whitehouse, G. Mayrhofer… in Inflammation Research (1996)

  4. No Access

    Article

    A comparison between the effects of meloxicam and other nsaids on the production of oxyradicals by human polymorphonuclear leucocytes

    Some non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the production or actions of oxygen radicals generated by polymorphonuclear leucocytes (PMNs); this mechanism may contribute towards their anti-infla...

    K. D. Rainsford, I. Ginsburg, S. J. Gadd in InflammoPharmacology (1997)