-
Article
A comparison between the effects of meloxicam and other nsaids on the production of oxyradicals by human polymorphonuclear leucocytes
Some non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the production or actions of oxygen radicals generated by polymorphonuclear leucocytes (PMNs); this mechanism may contribute towards their anti-infla...
-
Article
Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: The regulation of lymph node cell populations and cytokine production
A single dose of either cyclosporin-A (CsA) or lobenzarit (CCA) given with an arthrogenic adjuvant completely prevented expression of experimental adjuvant arthritis in rats. The aim of this study was to under...
-
Article
Is aspirin a prodrug for antioxidant and cytokine-modulating oxymetabolites
Aspirin and salicylate are transformed by stimulated human polymorphonuclear leucocytes (PMN), likely to be found at inflammatory sites, into both 2,3- and 2,5-dihydroxybenzoates (DHB). These DHB inhibit both ...
-
Article
Conditional pharmacology: II. Ambivalent effects of aurocyanide, a putative active metabolite of anti-arthritic gold drugs, on human and rat PMN leucocytes
Aurocyanide, and to a lesser extent, aurothiomalate and aurothiosulphate, showed diverse antioxidant/pro-oxidant effects on PMN leucocytes when stimulated ex-vivo to generate hydrogen peroxide. In normal human...
-
Article
Phenotypic analysis of functionally associated molecules on peripheral blood and synovial fluid monocytes from arthritis patients
Surface expression of 16 different membrane molecules was analyzed in peripheral blood and synovial fluid monocytes from patients with rheumatoid arthritis and reactive arthritis compared to controls. The most...