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Article
Open AccessAuthor Correction: Universal DNA methylation age across mammalian tissues
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Article
Open AccessUniversal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of u...
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Article
Open AccessAn epigenome-wide association study meta-analysis of educational attainment
The epigenome is associated with biological factors, such as disease status, and environmental factors, such as smoking, alcohol consumption and body mass index. Although there is a widespread perception that ...
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Article
Open AccessPeripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid
The blood–brain barrier separates circulating blood from the central nervous system (CNS). The scope of this barrier is not fully understood which limits our ability to relate biological measurements from peri...
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Article
Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes
Reduced expression of the Gad1 gene-encoded 67-kDa protein isoform of glutamic acid decarboxylase (GAD67) is a hallmark of schizophrenia. GAD67 downregulation occurs in multiple interneuronal sub-populations, inc...
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Article
Hippocampal immunostaining of CCK-GAD1 transgenic mice
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Article
Modulation of behavioral networks by selective interneuronal inactivation
Gamma-aminobutyric acid (GABA)-ergic disturbances are hallmark features of schizophrenia and other neuropsychiatric disorders and encompass multiple interneuronal cell types. Using bacterial artificial chromos...
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Article
Open AccessSeasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR
Studying monoaminergic seasonality is likely to improve our understanding of neurobiological mechanisms underlying season-associated physiological and pathophysiological behavior. Studies of monoaminergic seas...
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Article
Open AccessNovel animal models for studying complex brain disorders: BAC-driven miRNA-mediated in vivo silencing of gene expression
In schizophrenia, glutamic acid decarboxylase 1 (GAD1) disturbances are robust, consistently observed, cell-type specific and represent a core feature of the disease. In addition, neuropeptide Y (NPY), which i...
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Article
Three dimensional asperity analysis of worn surfaces
An algorithm has been developed for the analysis of asperities of various types of machined surfaces, in order to characterize wear processes in the course of dry friction. Wear experiments and surface roughne...
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Article
H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population
In this study, we examine the frequency of a 900 kb inversion at 17q21.3 in the Gypsy and Caucasian populations of Hungary, which may reflect the Asian origin of Gypsy populations. Of the two haplotypes (H1 and H...
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Chapter
Stereotactic stimulation of the anterior lobe of the cerebellum in cerebral palsy from a suboccipital approach
The anatomical connections of the anterior lobe of the cerebellum with the reticular formation in the brainstem, upper motor neurons and the limbic system, as well as the results of experimental and clinical o...
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Article
Erratum: Gene expression profiling identifies molecular subtypes of gliomas
Correction to: Oncogene 2003 22: 4918–4923. doi:10.1038/sj.onc.1206753 Due to a typesetting error, on page 4920 the Supplementary Information was referred to as ‘Supplementary Figure x’. It should have read, ‘...
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Article
Molecular markers associated with leptinine production are located on chromosome 1 in Solanum chacoense
Leptines of Solanum chacoense are effective natural deterrents against the Colorado potato beetle. Leptines are the acetylated forms of the glycoalkaloids solanine and chaconine and are supposed to be synthesised...
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Chapter and Conference Paper
Formal languages consisting of primitive words
Let Q be the set of primitive words over a finite alphabet having at least two letters. We prove that Q has two rather strong context-free-like properties. The first one is that Q satisfies the nonempty, strong v...
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Article
Book reviews
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Article
Blood supply of the bed nucleus of the stria terminalis in rat
The topographical distribution of the blood vessels in the bed nucleus of the stria terminalis (NIST) has been mapped in rats. Arteries and veins were visualized in red and blue by using a double-ink perfusion...
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Article
A microchemical facility for the analysis and synthesis of genes and proteins
A series of automated instruments that use state-of-the-art chemical methods has been developed for high-sensitivity protein sequencing, DNA synthesis and peptide synthesis. These intruments have been integrat...
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Article
Book review
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Article
Estimation of hemagglutination-inhibition titers
In the hemagglutination-inhibition test, simple relationships exist between units of hemagglutinating virus and hemagglutination-inhibition antibody titers. Equations have worked out which allow estimating ant...
