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Article
Hypomelanotic macules in tuberous sclerosis
Hypomelanotic macules of the skin in tuberous sclerosis (TS) are caused by a complex process, involving the synthesis and maturation of melanosomes. A quantitative method was developed to investigate the matur...
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Chapter
Immunohistopathological Aspects of Cutaneous Melanoma and Precursor Lesions
The presence of particular cellular chemical constituants can be demonstrated immunohistologically by visualizing the binding of specific antibodies to the constituants (antigens) in tissue sections. The natur...
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Chapter
Class II HLA Antigens in Benign and Malignant Lesions of Melanocytic Origin
Following the unexpected detection of immunologically functional class II HLA antigens on melanoma cells in long–term culture [1, 2], several investigators have analyzed the expression of these antigens by sur...
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Article
Monoclonal antibodies in detection of choroidal melanoma
Three monoclonal antibodies (MoAbs) prepared against cutaneous melanomas were tested against one group of 12 choroidal melanomas with indirect immunofluorescence in frozen sections. A fourth MoAb was tested in...
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Chapter
Pathological Changes in Hereditary Cerebral Hemorrhage with Amyloidosis — Dutch Type
Neuropathological findings in hereditary cerebral hemorrhage with amyloidosis — Dutch type are described.
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Article
Morphology of cerebral plaque-like lesions in hereditary cerebral hemorrhage with amyloidosis (Dutch)
We studied the presence and morphology of plaque-like lesions in the frontal cortex of six patients, aged 40 to 76 years, with hereditary cerebral hemorrhage with amyloidosis — Dutch type (HCHWA-D), using β/A4...
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Article
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology
Plaque-like lesions and amyloid angiopathy were investigated in the frontal cerebral cortex of four patients with hereditary cerebral hemorrhage with amyloidosis (Dutch) (HCHWA-D), using immunohistochemical [a...
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Article
Numerous and widespread α-synuclein-negative Lewy bodies in an asymptomatic patient
Lewy bodies (LB) and pale bodies (PB), their putative precursors, can be found in a spectrum of diseases characterized by parkinsonism and/or dementia. Furthermore, LB are occasionally observed in some other ...
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Article
CNS involvement in primary Sjögren’s syndrome: a case with a clue for the pathogenesis
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Article
Age-related plaque morphology and C-terminal heterogeneity of amyloid β in Dutch-type hereditary cerebral hemorrhage with amyloidosis
The evolvement of amyloid β (Aβ) deposition in the frontal cerebral cortex of 24 patients of increasing age with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D) was studied using end-spec...
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Article
Inclusion body myositis
The clinical features of inclusion body myositis (IBM) were of minor importance in the design of consensus diagnostic criteria, mainly because of controversial views on the specificity of signs and symptoms, a...
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Article
Open AccessLumbar disc extrusions reduce faster than bulging discs due to an active role of macrophages in sciatica
This retrospective observational histological study aims to associate the size and type of disc herniation with the degree of macrophage infiltration in disc material retrieved during disc surgery in patients ...