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    Article

    Mesolimbic dopamine function is not altered during continuous chronic treatment of rats with typical or atypical neuroleptic drugs

    Rats were treated continuously for up to 20 months with either haloperidol (1.4–1.6 mg/kg/day), sulpiride (102–109 mg/kg/day) or clozapine (24–27 mg/kg/day). Bmax for specific mesolimbic binding of3H-spiperone,3H...

    Nadia M. J. Rupniak, M. D. Hall, E. Kelly, S. Fleminger… in Journal of Neural Transmission (1985)

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    Chapter and Conference Paper

    Long-Term Adaptive Changes in Striatal Dopamine Function in Response to Chronic Neuroleptic Intake in Rats

    Chronic neuroleptic drug administration to rats reverses initial dopamine receptor blockade so that animals exhibit striatal dopamine receptor supersensitivity. This effect may be of functional significance in...

    Dr. P. Jenner, R. Kerwin, N. M. J. Rupniak… in Basic Aspects of Receptor Biochemistry (1983)