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  1. No Access

    Article

    Mesolimbic dopamine function is not altered during continuous chronic treatment of rats with typical or atypical neuroleptic drugs

    Rats were treated continuously for up to 20 months with either haloperidol (1.4–1.6 mg/kg/day), sulpiride (102–109 mg/kg/day) or clozapine (24–27 mg/kg/day). Bmax for specific mesolimbic binding of3H-spiperone,3H...

    Nadia M. J. Rupniak, M. D. Hall, E. Kelly, S. Fleminger… in Journal of Neural Transmission (1985)

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    Article

    Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat

    Administration of haloperidol (1.4–1.6 mg/kg/day) for up to 12 months or sulpiride (102–109 mg/kg/day) for between 6 and 12 months increased the frequency of purposeless chewing jaw movements in rats. N,n-propyln...

    N. M. J. Rupniak, S. Mann, M. D. Hall, S. Fleminger, G. Kilpatrick… in Psychopharmacology (1984)

  3. No Access

    Chapter and Conference Paper

    Long-Term Adaptive Changes in Striatal Dopamine Function in Response to Chronic Neuroleptic Intake in Rats

    Chronic neuroleptic drug administration to rats reverses initial dopamine receptor blockade so that animals exhibit striatal dopamine receptor supersensitivity. This effect may be of functional significance in...

    Dr. P. Jenner, R. Kerwin, N. M. J. Rupniak… in Basic Aspects of Receptor Biochemistry (1983)