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Open AccessAtmospheric transport is a major pathway of microplastics to remote regions
In recent years, marine, freshwater and terrestrial pollution with microplastics has been discussed extensively, whereas atmospheric microplastic transport has been largely overlooked. Here, we present global ...
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Article
Open AccessThe sources of atmospheric black carbon at a European gateway to the Arctic
Black carbon (BC) aerosols from incomplete combustion of biomass and fossil fuel contribute to Arctic climate warming. Models—seeking to advise mitigation policy—are challenged in reproducing observations of s...
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Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative, for the treatment of patients with non-small cell lung cancer
The purpose of this phase I study was to evaluate the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), the recommended dose for phase II study, pharmacokinetics, and antitumor activity of TZT-1027 (...
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Male breast cancer
A 71-year-old male patient had been aware for 3 years of a slowly-growing nodule in his left breast that began to produce a discharge in the 3 months prior to his presentation. The discharge became progressive...
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Article
Isolated dihydroxyacetonephosphate acyltransferase deficiency presenting with developmental delay
A boy aged 21 months who was being investigated for developmental delay and failure to thrive was found to have punctate epiphyseal calcification. He had no evidence of rhizomelic shortening of the limbs or ca...
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Article
Combination of daily 4-h infusion of 5-fluorouracil and cisplatin in the treatment of advanced head and neck squamous-cell carcinoma: A South-East European Oncology Group study
Between April 1986 and May 1989 a multicéntre study was conducted to evaluate the efficacy of a 4-h intravenous infusion of 1000 mg/m2 5-fluorouracil (5-FU) followed by a 1-h infusion of 25 mg/m2 cisplatin (CDDP)...
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Phase II study of 4′-Epi-Doxorubicin in patients with untreated, extensive small Cell Lung Cancer
The purpose of the study was to investigate the antitumour activity and toxicity of high dose (120 mg m-2) single agent epirubicin therapy in untreated extensive small cell lung cancer patients. Out of 80 patient...
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Book reviews
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Clinical Trials
Clinical trials can be defined as carefully designed scientific investigations that generate data in order to evaluate therapeutic methods in a patient population. In recent years a clinical trials discipline ...
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Cancer Control
Cancer control, in its broadest sense, includes prevention, screening, early diagnosis, staging, treatment, rehabilitation, continuing, and terminal care of cancer patients. The ultimate objective of cancer co...
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Systemic Therapies
Several malignancies, such as the leukemias and lymphomas, manifest as generalized neoplastic diseases not amenable to surgery or radiotherapy. Other cancers metastasize before they have been diagnosed and pat...
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Diagnosis, Staging, and Principles of Management
A diagnosis of cancer depends on the patient’s consulting a physician. This in turn depends on the patient’s knowledge of health problems. At one extreme a patient may know that if he has pain or bleeding, he ...
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Book
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Introduction
Part II of this Manual is purely clinical in character and covers malignant tumours of various organs and systems. It is designed to provide the basic clinical information and concepts required by every physic...
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Introduction
The picture of clinical cancer research presents a changing kaleidoscope of fact and theory, of hope and expectation, of boundless promise and selective reward. In this report a few facets of that picture, tho...
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Bone and Soft Tissue
Bone tumours are relatively rare. Their incidence varies according to age. While the frequency of osteogenic sarcoma and Ewing ’s sarcoma is higher in childhood than in adults, the opposite is true for chondro...
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Childhood Cancers
The commonest causes of death in children differ from one country to another. They include infection and malnutrition, accidents, cancer and congenital malformations. Cancer is a rare disease in childhood, aff...
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Multiple Myeloma
Multiple myeloma (plasmocytoma, myelomatosis) is a disease resulting from the uncontrolled proliferation of one or more clones of plasma (myeloma) cells. In most instances, the bone marrow is diffusely infiltr...
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Cancer Diagnosis
Innovative applications of established techniques, new developments in medical technology and advances in genetic theory have significantly extended our ability to diagnose patients with cancer and to monitor ...
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Acquired Immune Deficiency Syndrome
The acquired immunodeficiency syndrome (AIDS) is a disease which first appeared in the United States in 1979 and came to the attention of the medical community in 1981 [387]. The disease is characterised by a ...
