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  1. Article

    Open Access

    Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice

    TGF-β signaling in liver cells has variant roles in the dynamics of liver diseases, including hepatocellular carcinoma (HCC). We previously found a correlation of high levels of the important endogenous negati...

    T Feng, J Dzieran, X Yuan, A Dropmann, T Maass, A Teufel, S Marhenke… in Oncogenesis (2017)

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  2. Article

    Open Access

    Caveolin-1 is required for TGF- β -induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

    Transforming growth factor-beta (TGF-β) plays a dual role in hepatocytes, inducing both pro- and anti-apoptotic responses, whose balance decides cell fate. Survival signals are mediated by the epidermal growth fa...

    J Moreno-Càceres, L Caja, J Mainez, R Mayoral, P Martín-Sanz… in Cell Death & Disease (2014)

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  3. Article

    Open Access

    Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis

    Transforming growth factor (TGF)-β has a dual role in liver, providing cytostatic effects during liver damage and regeneration, as well as carcinogenic functions in malignant transformation and hepatocellular can...

    C Meyer, Y Liu, A Kaul, I Peipe, S Dooley in Cell Death & Disease (2013)

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