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  1. Article

    Open Access

    Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice

    TGF-β signaling in liver cells has variant roles in the dynamics of liver diseases, including hepatocellular carcinoma (HCC). We previously found a correlation of high levels of the important endogenous negati...

    T Feng, J Dzieran, X Yuan, A Dropmann, T Maass, A Teufel, S Marhenke… in Oncogenesis (2017)

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  2. Article

    Open Access

    Caveolin-1 is required for TGF- β -induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

    Transforming growth factor-beta (TGF-β) plays a dual role in hepatocytes, inducing both pro- and anti-apoptotic responses, whose balance decides cell fate. Survival signals are mediated by the epidermal growth fa...

    J Moreno-Càceres, L Caja, J Mainez, R Mayoral, P Martín-Sanz… in Cell Death & Disease (2014)

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  3. Article

    Open Access

    Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis

    Transforming growth factor (TGF)-β has a dual role in liver, providing cytostatic effects during liver damage and regeneration, as well as carcinogenic functions in malignant transformation and hepatocellular can...

    C Meyer, Y Liu, A Kaul, I Peipe, S Dooley in Cell Death & Disease (2013)

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  4. No Access

    Chapter and Conference Paper

    NeoHepatocytes generated from patients with chronic liver disease can be used for autologous cell transplantation

    Liver transplantation is the only definitive treatment for end stage liver disease. Donor organ scarcity raises a growing interest in new therapeutic options. Recently, we have shown that injection of monocyte...

    S. Ehnert, A. Lehmann, U. Böcker, S. Dooley… in Chirurgisches Forum und DGAV Forum 2009 (2009)

  5. Article

    Outcome of infants born to hepatitis C infected women

    Hepatitis C virus (HCV) can be transmitted vertically from mother to infant, either late in pregnancy or at delivery.

    C. M. Healy, M. T. Cafferkey, A. Conroy, S. Dooley… in Irish Journal of Medical Science (2001)

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  6. Article

    Selected abstracts

    P. P. Corkery, B. F. Leek, B. Caulfield, M. Garrett… in Irish Journal of Medical Science (2000)

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  7. No Access

    Article

    Hepatitis C infection in an Irish antenatal population

    Hepatitis C infection (HCV) has an estimated seroprevalence of 1–2% in women of child-bearing age and vertical transmission rate of 5–15%.

    C. M. Healy, M. T. Cafferkey, A. Conroy, S. Dooley… in Irish Journal of Medical Science (2000)

  8. No Access

    Chapter and Conference Paper

    UVB Irradiation, Mismatch Repair and Cutaneous Melanoma

    Msh2 is one of the genes involved in DNA-mismatch repair. Mutations in the coding region of the human gene (hmsh2) have been shown to be directly involved in microsatellite instability in hereditary nonpolypos...

    S. Dooley in Skin Cancer and UV Radiation (1997)

  9. No Access

    Article

    Irish Society of Gastroenterology

    P. K. Neelamakam, E. Brazil, S. Attwood, O. Traynor… in Irish Journal of Medical Science (1995)

  10. No Access

    Article

    Messenger RNA fluorescence in situ hybridization technique in tumor tissue sections

    V. Jung, S. Urbschat, S. Dooley, H. Bonkhoff… in Journal of Cancer Research and Clinical On… (1995)

  11. No Access

    Article

    Royal academy of medicine in Ireland section of dermatology

    W. J. O’Connor, L. Barnes, G. Gibson, T. O’Grady… in Irish Journal of Medical Science (1993)

  12. No Access

    Article

    Q fever in the republic of Ireland: An update

    During the years 1975–1978, 28 new cases of Q fever were confirmed by the finding of significant complement fixing antibody titres toC. burneti. Almost half of these (46%) were patients with severe cardiac involv...

    Irene B. Hillary, S. Dooley, P. N. Meenan in Irish Journal of Medical Science (1980)