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  1. No Access

    Article

    Evaluation of the GastroPlus™ Advanced Compartmental and Transit (ACAT) Model in Early Discovery

    The aim of this study was to evaluate the oral exposure predictions obtained early in drug discovery with a generic GastroPlus Advanced Compartmental And Transit (ACAT) model based on the in vivo intravenous bloo...

    N. Gobeau, R. Stringer, S. De Buck, T. Tuntland, B. Faller in Pharmaceutical Research (2016)

  2. No Access

    Article

    Intracorporeal rectal stapling following laparoscopic total mesorectal excision

    Division of the rectum following total mesorectal excision (TME) using intracorporeal stapling devices is technically difficult due to their width and limited roticulation. More than one cartridge is often req...

    A. E. Brannigan, S. De Buck, P. Suetens… in Surgical Endoscopy And Other Interventiona… (2006)

  3. No Access

    Article

    Single-copy T-DNAs integrated at different positions in the Arabidopsis genome display uniform and comparable β-glucuronidase accumulation levels

    This study aimed at determining whether transgene expression variability is observed in single-copy T-DNA plants and whether it can be correlated with the T-DNA integration position. Among a population of 135 Ara...

    S. De Buck, P. Windels, M. De Loose… in Cellular and Molecular Life Sciences CMLS (2004)

  4. No Access

    Article

    Identification and characterization of T-DNA inserts by T-DNA fingerprinting

    A T-DNA fingerprinting method is presented based on amplified fragmentlength polymorphism with an anchored polymerase chain reaction step. Thismethod allows discrimination between different T-DNA inserts in st...

    I. Theuns, P. Windels, S. De Buck, A. Depicker, E. Van Bockstaele, M. De Loose in Euphytica (2002)

  5. No Access

    Article

    Disruption of their palindromic arrangement leads to selective loss of DNA methylation in inversely repeated gus transgenes in Arabidopsis

    The transgene locus KH15, which is highly susceptible to silencing in Arabidopsis thaliana, contains two inversely repeated β-glucuronidase (gus) genes separated by a palindromic sequence and has a low GUS activ...

    S. De Buck, A. Depicker in Molecular Genetics and Genomics (2001)

  6. No Access

    Article

    Gene silencing results in instability of antibody production in transgenic plants

    The stability of antibody and Fab expression was assessed in five different homozygous transgenic Arabidopsis lines. Each of these lines showed silencing of the transgenes that encode the antibody polypeptides, ...

    M. De Neve, S. De Buck, C. De Wilde, H. Van Houdt… in Molecular and General Genetics MGG (1999)