-
Article
Open AccessComparing medication adherence in patients receiving bisphosphonates for preventing fragility fractures: a comprehensive systematic review and network meta-analysis
Bisphosphonates are effective in preventing fragility fractures; however, high rates of adherence are needed to preserve clinical benefits.
-
Article
Open AccessAcute respiratory infection symptoms and COVID-19 testing behaviour: results based on South Australian health surveys
Effective syndromic surveillance alongside COVID-19 testing behaviours in the population including in higher risk and hard to reach subgroups is vital to detect re-emergence of COVID-19 transmission in the com...
-
Article
Computed tomography imaging in ventral hernia repair: can we predict the need for myofascial release?
Currently, the need for additional myofascial release (AMR) in addition to retromuscular dissection during open Rives–Stoppa hernia repair is determined intraoperatively based on the discretion of the surgeon....
-
Article
Open AccessExit strategies: optimising feasible surveillance for detection, elimination, and ongoing prevention of COVID-19 community transmission
Following implementation of strong containment measures, several countries and regions have low detectable community transmission of COVID-19. We developed an efficient, rapid, and scalable surveillance strate...
-
Article
Open AccessAn observational cohort study to produce and evaluate an improved tool to screen older women with back pain for osteoporotic vertebral fractures (Vfrac): study protocol
The aim of this study is to produce an easy to use checklist for general practitioners to complete whenever a woman aged over 65 years with back pain seeks healthcare. This checklist will produce a binary outp...
-
Article
Open AccessCost implications for the NHS of using the Alere™ i Influenza A & B near patient test with nasal swabs
Influenza is an acute viral infection of the respiratory tract. A rapid confirmatory diagnosis of influenza is important, since it is highly transmissible and outbreaks of influenza within the hospital setting...
-
Article
Role of pseudo-turbulent stresses in shocked particle clouds and construction of surrogate models for closure
Macroscale models of shock–particle interactions require closure terms for unresolved solid–fluid momentum and energy transfer. These comprise the effects of mean as well as fluctuating fluid-phase velocity fi...
-
Article
RARRES2 functions as a tumor suppressor by promoting β-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma
Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both im...
-
Article
TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer
The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related TP63 isoform ΔNp63 in squamous cancers. Further, a...
-
Article
Recurrent activating mutations of CD28 in peripheral T-cell lymphomas
Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-cell neoplasms with a poor prognosis. Recently, mutations in TET2 and other epigenetic modifiers as well as RHOA have been identif...
-
Article
Evaluation of models predicting insignificant prostate cancer to select men for active surveillance of prostate cancer
In an era of personalized medicine, individualized risk assessment using easily available tools on the internet and the literature are appealing. However, uninformed use by clinicians and the public raises pot...
-
Article
Isolation and characterization of progenitor mesenchymal cells in human pituitary tumors
The Cancer Stem Cells (CSCs) theory suggests that genetic alterations in stem cells are the direct cause for cancer. The evidence for a CSC population that results in pituitary tumors is poor. Some studies rep...
-
Article
Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma
Agents targeting the insulin-like growth factor-1 receptor (IGF1R) are in clinical development, but, despite some initial success of single agents in sarcoma, response rates are low with brief durations. Thus,...
-
Chapter
Vitamin D and dental health
Common oral diseases include gingivitis (inflammation of soft ‘gum’ tissue), periodontitis (infection of hard and soft tissues around teeth) and caries (infection of teeth). These conditions are influenced by ...
-
Article
Open AccessHigh frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias
In order to develop a xenograft model to determine the efficacy of new therapies against primary human precursor-B acute lymphoblastic leukemia (ALL) stem cells (LSCs), we used the highly immunodeficient non-o...
-
Article
Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
Limited information is available regarding epigenomic events mediating initiation and progression of tobacco-induced lung cancers. In this study, we established an in vitro system to examine epigenomic effects of...
-
Article
Human leukocyte antigen (HLA) A1-B8-DR3 (8.1) haplotype, tumor necrosis factor (TNF) G-308A, and risk of non-Hodgkin lymphoma
-
Article
Poster presentations
-
Article
Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma
-
Article
The abundance threshold for plague as a critical percolation phenomenon
Percolation theory is a part of statistical physics that deals with the slow flow of liquid through porous media, and is more generally extended to consider the formation of long-range connectivity in a random...
