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Article
PML-mediated signaling and its role in cancer stem cells
The promyelocytic leukemia (PML) protein, initially discovered as a part of the PML/retinoic acid receptor alpha fusion protein, has been found to be a critical player in oncogenesis and tumor progression. Mul...
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Article
Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases
Secreted protein acidic and rich in cysteine (SPARC) is an extracellular glycoprotein expressed in several solid cancers, including malignant gliomas, upon adoption of metastatic or invasive behaviors. SPARC e...
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Article
Modeling the Spontaneous Activity of the Auditory Cortex
We present a rate model of the spontaneous activity in the auditory cortex, based on synaptic depression. A Stochastic integro-differential system of equations is derived and the analysis reveals two main regi...