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Article
Open AccessBevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients
Bevacizumab improves outcome for most recurrent glioblastoma patients, but the duration of benefit is limited and survival after initial bevacizumab progression is poor. We evaluated bevacizumab continuation b...
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Article
Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) where aberrant signaling downstream of this receptor contributes to tumor growth. EGFR varia...
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Article
Open AccessMetronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study
We evaluated bevacizumab with metronomic etoposide among recurrent malignant glioma patients in a phase 2, open-label trial.
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Article
Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases
Secreted protein acidic and rich in cysteine (SPARC) is an extracellular glycoprotein expressed in several solid cancers, including malignant gliomas, upon adoption of metastatic or invasive behaviors. SPARC e...
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Article
Characterization of chromosome 17 abnormalities in medulloblastomas
Loss of portions of chromosome 17p, usually through the formation of i(17qp) is a well-known finding in medulloblastomas. Loss of heterozygosity (LOH) studies, however, occasionally demonstrate loss of the mo...
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Article
Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea
The prognosis for patients with malignant gliomas continues to be dismal. The high degree of resistance of gliomas to nitrosourea-based chemotherapy is one major factor in poor treatment outcome. The identifi...
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Chapter and Conference Paper
Two Approaches for Enhancing Radioimmunotherapy: ∝ Emitters and Hyperthermia
The lack of specificity of chemotherapy and external beam radiation frequently results in toxicity to normal organs, limiting doses to below those at which tumor control would be reached. Because of its potent...
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Article
Abstracts
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Article
Disialoganglioside GD2 in human neuroectodermal tumor cell lines and gliomas
Monoclonal antibodies (mAbs) recognizing the disialoganglioside II3(NeuAc)2GgOse3Cer (GD2) were produced by immunizing mice with the GD2-expressing neuroblastoma cell line LAN-1 and a prefusion boost with purifie...
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Article
GD3 expression by cultured human tumor cells of neuroectodermal origin
Seven monoclonal antibodies (mAbs) reactive with ganglioside II3(NeuAc)2-LacCer (GD3) were generated; four of these mAbs (DMAb-21, DMAb-22, DMAb-23, and DMAb-24) by immunizing mice with GD3 adsorbed to Salmonella...
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Article
Ganglioside map** of a human medulloblastoma xenograft
The ganglioside patterns of medulloblastomas have never been established; in this study we report the ganglioside profile of the human medulloblastoma cell line TE-671 grown as a xenograft in nude mice. Gangli...
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Article
Growth effects of epidermal growth factor (EGF) and a monoclonal antibody against the EGF receptor on four glioma cell lines
Epidermal growth factor (EGF) has been shown to stimulate DNA synthesis and cell division in normal glia. At least half of malignant human gliomas (MHG) express high levels of the EGF receptor (EGFR), which ar...
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Article
Invasiveness of human glioma cell lines in vitro: Relation to tumorigenicity in athymic mice
Five established cell lines derived from human anaplastic astrocytomas or glioblastoma multiforme were tested for invasiveness into precultured chick heart fragments in vitro. Four of the cell lines (U118 MG, ...
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Article
Hydroxyurea synchronization increases mitotic yield in human glioma cell lines
Karyotypic studies of human gliomas are often limited by a low mitotic index and the appearance of contracted chromosomes that do not exhibit clear banding patterns. The purpose of this study was to investigat...
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Chapter
The Applications of Monoclonal Antibodies in Neuro-Oncology
Central nervous system (CNS) malignancies represent one ofthe most devastating forms of cancer. Malignant gliomas, the most commonly occurring primary tumor of the CNS, have a particularly bleak prognosis desp...
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Chapter and Conference Paper
Selective Effect of Adenosine on Tumor Blood Flow
Brain tumor chemotherapy is limited by insufficient drug delivery to the tumor (1, 5). Delivery of water-soluble drugs is impaired by the partially intact blood-brain barrier (BBB), while delivery of drugs which ...
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Article
Specific chromosomal abnormalities characterize four established cell lines derived from malignant human gliomas
The four permanent human glioma-derived cell lines reported here are the first such lines for which the karyotypes have been followed from the original biopsies through the establishment of the lines in cultur...
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Chapter
Chromosomes and chromosomal progression of malignant human gliomas: theoretical and practical implications
We karyotyped 27 malignant human gliomas including 3 anaplastic astrocytomas (AA), 23 glioblastoma multiformes (GBM), and 1 gliosarcoma (GS) in direct preparation, short term culture, or both, and found that t...
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Article
A preliminary study utilizing viable HLA mismatched cultured glioma cells as adjuvant therapy for patients with malignant gliomas
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Article
Localization of factor VIII/von willebrand factor and glial fibrillary acidic protein in the hemangioblastoma: Implications for stromal cell histogenesis
The histogenesis of hemangioblastoma stromal cells is unresolved. Ultrastructural observations suggest that the stromal cells, endothelial cells, and pericytes that compose this neoplasm are all derived from a...
