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  1. No Access

    Article

    Haemodynamic interactions of a new calcium sensitizing drug levosimendan and captopril

    Objective: Levosimendan in a new inodilator drug that sensitises troponin C in heart muscle cells to calcium, thus improving contractility. In previous studies, a single 2 mg intravenous dose of levosimendan inc...

    S. Antila, L. Lehtonen, E.-P. Sandell, J. Eha… in European Journal of Clinical Pharmacology (1996)

  2. No Access

    Article

    COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers

    We studied the effects of entacapone, a novel inhibitor of the enzyme catechol-O-methyltransferase (COMT), on spontaneous and levodopa (LD) modulated secretion of growth hormone (GH) and prolactin (PRL) in 12 ...

    T. Keränen, A. Gordin, M. Koulu, M. Scheinin, S. Antila… in Journal of Neural Transmission (1996)

  3. No Access

    Article

    Pharmacokinetics of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, in man

    Objective: This study investigated the pharmacokinetics of the catechol-O-methyltransferase (COMT) inhibitor entacapone by giving simultaneously stable non-radioactive isotope 13C-entacapone int...

    H. Heikkinen, M. Saraheimo, S. Antila… in European Journal of Clinical Pharmacology (2001)