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  1. No Access

    Article

    A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation

    Interleukin-11 (IL-11) decreases cytokine release and increases survival in murine BMT models. In these systems, it reduces gut permeability, partially polarizes T cells to a Th2 phenotype, down-regulates IL-1...

    JH Antin, SJ Lee, D Neuberg, E Alyea, RJ Soiffer, S Sonis… in Bone Marrow Transplantation (2002)

  2. No Access

    Article

    The biological basis for the attenuation of mucositis: the example of interleukin-11

    Oral mucositis is common, painful, dose-limiting toxicity of drug and radiation therapy for cancer. In granulocytopenic patients, the ulcerations which accompany mucositis are frequent portals of entry for ind...

    S Sonis, L Edwards, C Lucey in Leukemia (1999)