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Article
A phase I, dose escalation, pharmacodynamic, pharmacokinetic, and food-effect study of α2 integrin inhibitor E7820 in patients with advanced solid tumors
Introduction E7820 is an orally administered sulfonamide that inhibits alfa-2-integrin mRNA expression. Pre-clinically E7820 showed tumor anti-angiogenic effects in various tumor cell lin...
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Article
Clinical experience with a simple algorithm for plerixafor utilization in autologous stem cell mobilization
Plerixafor augments PBSC collection, but the optimal approach for incorporating it into mobilization is uncertain. Forty-nine consecutive patients mobilized with G-CSF alone were analyzed, and a day 4 peripher...
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Article
Open AccessProspective surveillance of women with a family history of breast cancer: auditing the risk threshold
To evaluate current guidelines criteria for inclusion of women in special ‘breast cancer family history’ surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinic...
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Chapter and Conference Paper
Full Genome Sequence of Azotobacter vinelandii: Preliminary Analysis
One of the most versatile and widely studied diazotrophs is Azotobacter vinelandii, which has a diversity of features that are of interest to several scientific communities. In addition to having three distinct n...
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Chapter and Conference Paper
Outcome of Patients with Refractory/Recurrent Acute Myelogenous Leukaemia (AML) Treated at a Single Centre
Although complete remission (CR) can now be achieved in most younger patients with AML with the use of combination chemotherapy and improved supportive care, this does not lead to long term cure in the majorit...
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Article
Open AccessIrinotecan, cisplatin and mitomycin in inoperable gastro-oesophageal and pancreatic cancers – a new active regimen
Irinotecan, mitomycin and cisplatin all demonstrate activity in gastro-oesophageal cancers. This novel combination was administered to outpatients with previously untreated inoperable gastro-oesophageal or pan...
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Article
Acute promyelocytic leukaemia: a retrospective analysis of patients treated at St. Bartholomew's Hospital 1969–1995
Seventy-two patients with acute promyelocytic leukemia (APML) were treated at St.Bartholomew's Hospital (SBH) over a 25-year period. Improvements in supportive care and the use of more intensive chemotherapy ...
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Chapter
Transfer of SV40 - T Expression Vectors into Human Monocytes
The expression of foreign DNA in human peripheral blood cells is notoriously difficult. In an effort to find a more efficient system for gene transfer the transient expression of SV40 T antigen has been invest...
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Article
Sexual victimization in the history of sexual abusers: A review
The present paper reviews the empirical literature on the proportion of child sexual abusers who were themselves sexually victimized as children. While findings in individual studies ranged between 0% and 67%,...
