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Article
Erratum: Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer
Correction to: Oncogene (2016) 35, 691–701; doi:10.1038/onc.2014.469; published online 2 February 2015 Since the online publication of this article we have amended CV Pecot’s name to include the author’s middl...
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Article
Open AccessFunctional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer
The myc oncogene is overexpressed in almost half of all breast and ovarian cancers, but attempts at therapeutic interventions against myc have proven to be challenging. Myc regulates multiple biological proces...
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Article
Tumor Prevention by 9-Cis-Retinoic Acid in the N-Nitroso-N-Methylurea Model of Mammary Carcinogenesis is Potentiated by the Pineal Hormone Melatonin
Our laboratory has demonstrated that treatment of MCF-7 breast cancer cells with melatonin (Mlt) followed 24 h later with physiological concentrations of all-trans retinoic acid (atRA) results in apoptosis. These...
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Article
Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells
We have previously demonstrated that the pineal hormone, melatonin, can inhibit the growth of estrogen receptor-alpha (ERα)-positive breast cancer cells and suppress ERα gene transcription. To investigate the ...
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Chapter
Hormone Receptors and Risk in Breast Cancer
It has long been appreciated that some metastatic breast cancers were susceptible to hormonal influences and would respond to hormonal manipulation. The discovery of steroid hormone receptors in some breast ca...