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Article
EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia
Overexpression of the ecotropic virus integration-1 (EVI1) gene (EVI1+), localized at chromosome 3q26, is associated with adverse outcome in adult acute myeloid leukemia (AML). In pediatric AML, 3q26 abnormalitie...
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Article
Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo
Id1 is frequently overexpressed in many cancer cells, but the functional significance of these findings is not known. To determine if Id1 could contribute to the development of hematopoietic malignancy, we rec...
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Article
Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia