14 Result(s)

Article

Detection and prognostic significance of circulating tumour cells in patients with metastatic breast cancer according to immunohistochemical subtypes

The enumeration of circulating tumour cells (CTCs) with the EpCAM-based CellSearch system has prognostic significance in patients with metastatic breast cancer (MBC). The aim of this study was to explore poten...

D J E Peeters, P-J van Dam, G G M Van den Eynden, A Rutten… in British Journal of Cancer (2014)

Article

Semiautomated isolation and molecular characterisation of single or highly purified tumour cells from CellSearch enriched blood samples using dielectrophoretic cell sorting

Molecular characterisation of single circulating tumour cells (CTCs) holds considerable promise for predictive biomarker assessment and to explore CTC heterogeneity. We evaluate a new method, the DEPArray syst...

D J E Peeters, B De Laere, G G Van den Eynden, S J Van Laere… in British Journal of Cancer (2013)

Article

Circulating tumour cells in the central and the peripheral venous compartment in patients with metastatic breast cancer

The enumeration of circulating tumour cells (CTC) has prognostic significance in patients with metastatic breast cancer (MBC) and monitoring of CTC levels over time has considerable potential to guide treatmen...

D J E Peeters, G G Van den Eynden, P-J van Dam, A Prové… in British Journal of Cancer (2011)

Article

Integrated miRNA and mRNA expression profiling of the inflammatory breast cancer subtype

MicroRNAs (miRNAs) are key regulators of gene expression. In this study, we explored whether altered miRNA expression has a prominent role in defining the inflammatory breast cancer (IBC) phenotype.

I Van der Auwera, R Limame, P van Dam, P B Vermeulen… in British Journal of Cancer (2010)

Article

Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT–PCR in patients with metastatic breast cancer

The detection, enumeration and isolation of circulating tumour cells (CTCs) have considerable potential to influence the clinical management of patients with breast cancer. There is, however, substantial varia...

I Van der Auwera, D Peeters, I H Benoy, H J Elst… in British Journal of Cancer (2010)

Article

Inflammatory breast carcinoma as a model of accelerated self-metastatic expansion by intravascular growth

P B Vermeulen, S J Van Laere, L Y Dirix in British Journal of Cancer (2009)

Article

The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients

Circulating tumour cells (CTC) and tumour-related methylated DNA in blood have been separately assessed for their utility as a marker for subclinical metastasis in breast cancer. However, no studies have looke...

I Van der Auwera, H J Elst, S J Van Laere, H Maes, P Huget… in British Journal of Cancer (2009)

Article

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer

Vascular endothelial growth factor (VEGF)-A inhibitors exhibit unseen high responses and toxicity in recurrent epithelial ovarian cancer suggesting an important role for the VEGF/VEGFR pathway. We studied the ...

X B Trinh, W A A Tjalma, P B Vermeulen, G Van den Eynden… in British Journal of Cancer (2009)

Article

Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype

Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter occurs in about 40% of breast tumours and has been correlated with reduced APC protein levels. To what extent epigenetic alterations of t...

I Van der Auwera, S J Van Laere, S M Van den Bosch… in British Journal of Cancer (2008)

Article

NF-κB activation in inflammatory breast cancer is associated with oestrogen receptor downregulation, secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation

Activation of NF-κB in inflammatory breast cancer (IBC) is associated with loss of estrogen receptor (ER) expression, indicating a potential crosstalk between NF-κB and ER. In this study, we examined the activ...

S J Van Laere, I Van der Auwera, G G Van den Eynden, P van Dam… in British Journal of Cancer (2007)

Article

High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT–PCR mRNA expression profile

Clear cell renal cell carcinoma (CC-RCC) is a highly vascularised tumour and is therefore an attractive disease to study angiogenesis and to test novel angiogenesis inhibitors in early clinical development. En...

M M Baldewijns, V L Thijssen, G G Van den Eynden… in British Journal of Cancer (2007)

Article

Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer

We studied the presence of lymphangiogenesis in lymph node (LN) metastases of breast cancer. Lymph vessels were present in 52 of 61 (85.2%) metastatically involved LNs vs 26 of 104 (25.0%) uninvolved LNs (P<0.001...

G G Van den Eynden, I Van der Auwera, S J Van Laere… in British Journal of Cancer (2006)

Article

Distinguishing blood and lymph vessel invasion in breast cancer: a prospective immunohistochemical study

Recently, peritumoural (lympho)vascular invasion, assessed on haematoxylin–eosin (HE)-stained slides, was added to the St Gallen criteria for adjuvant treatment of patients with operable breast cancer (BC). Ne...

G G Van den Eynden, I Van der Auwera, S J Van Laere… in British Journal of Cancer (2006)

Article

Angiogenesis and hypoxia in lymph node metastases is predicted by the angiogenesis and hypoxia in the primary tumour in patients with breast cancer

Hypoxia and angiogenesis are important factors in breast cancer progression. Little is known of hypoxia and angiogenesis in lymph node metastases of breast cancer. The aim of this study was to quantify hypoxia...

G G Van den Eynden, I Van der Auwera, S J Van Laere… in British Journal of Cancer (2005)