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Article
Open AccessNeridronate for transient osteoporosis of the hip in a child
Transient osteoporosis of the hip (TOH) is usually reported in middle-aged men or during pregnancy as a benign self-limiting condition. Nevertheless, its impact on quality of life in terms of pain and disabil...
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Article
Open AccessMolecular profiling reveals primary mesothelioma cell lines recapitulate human disease
Malignant mesothelioma (MM) is an aggressive, fatal tumor strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinica...
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Article
Urbanization altered latitudinal patterns of bird diversity-environment relationships in the southern Neotropics
Given the global expansion of urbanization, it is crucial for planning to understand how that process affects spatial patterns of diversity. At broad geographical scales, climatic conditions such as temperatur...
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Article
Anticonvulsant drugs and hematological disease
Many antiepileptic drugs (AEDs) are associated with hematological disorders that range from mild thrombocytopenia or neutropenia to anemia, red cell aplasia, until bone marrow failure. Fortunately, potentiall...
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Article
Open AccessMiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
The resistance of hypoxic cells to radiotherapy and chemotherapy is a major problem in the treatment of cancer. Recently, an additional mode of hypoxia-inducible factor (HIF)-dependent transcriptional regulati...
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Article
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity
Following the identification of a set of hypoxia-regulated microRNAs (miRNAs), recent studies have highlighted the importance of miR-210 and of its transcriptional regulation by the transcription factor hypoxi...
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Article
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6
DJ-1 was recently identified as a gene product responsible for a subset of familial Parkinson's disease (PD). The mechanisms by which mutations in DJ-1 alter its function and account for PD-related pathology r...
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Article
Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells
Once cleaved by caspases, the Lyn tyrosine kinase (LynΔN) is relocalized from the plasma membrane to the cytoplasm of apoptotic cells, but the function of such a cleavage is incompletely understood. We evaluat...
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Article
Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition
Imatinib targets the Bcr-Abl oncogene that causes chronic myelogenous leukemia (CML) in humans. Recently, we demonstrated that besides triggering apoptosis in K562 cells, imatinib also mediated their erythroid...
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Article
291 Orbital Myositis Presenting as Cluster Headache
Background. Cluster headache affects men in the third decade of life. Episodes centers in and around eye, start acutely, last 1 to 2 hours, and occur several times a day. Associated features are ipsilateral co...
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Article
157 Biological Markers of Oxidative Stress in Progressive Muscular Dystrophies: A Preliminary Study
Background/Aims. Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are fatal degenerative disorders of muscle resulting from mutations in the gene coding for dystrophin. The exact mechanism...
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Chapter and Conference Paper
Estimating Path Flows from Traffic Counts
The theory and use of the Path Flow Estimator (PFE) as a one-stage network observer in support of urban traffic management and control is presented. Following an outline of the theory, initial results from the...
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Article
Growth hormone secretion in Prader-Willi syndrome
Prader-Willi Syndrome (PWS) is a multisystem defect characterized by obesity, hypogenitalism and short stature for genetic background. Low GH serum levels have been found in patients with PWS and were related ...
