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Article
Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategy
Tumor suppressor genes and oncogenes are both commonly altered during carcinogenesis. For oncogenes and other genes that drive growth, targeting mutated or activated forms (such as the EGFR-Her2/Nneu pathway) ...
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Article
Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk
SWI/SNF (SWItch/sucrose non-fermentable) complexes are ATP-dependent chromatin remodeling enzymes critically involved in the regulation of multiple functions, including gene expression, differentiation, develo...