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    Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples

    In acute myeloid leukemia (AML), activating mutations in the fms-like tyrosine kinase 3 (FLT3) gene predict poor prognosis. We determined FLT3 internal tandem duplications (FLT3/ITD) and D835 point mutations in p...

    J Cloos, B F Goemans, C J Hess, J W van Oostveen, Q Waisfisz, S Corthals… in Leukemia (2006)