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Correction: Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia
Following the publication of this article the authors noted that data describing precisely where phosphorylation sites in proteins modulated following JAK1 or JAK3 inhibition in mutant T-ALL samples was not cl...
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Open AccessDefining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system
T-cell acute lymphoblastic leukemia (T-ALL) is caused by the accumulation of multiple mutations combined with the ectopic expression of transcription factors in develo** T cells. However, the molecular basis...
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Open AccessMutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia
Mutations in the interleukin-7 receptor (IL7R) or the Janus kinase 3 (JAK3) kinase occur frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are able to drive cellular transformation and the dev...
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The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling
Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the pathogenic role of the recurrent R98S mutation in rib...
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21. Mainzer Allergie-Workshop
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Über den möglichen Einfluss der Ernährung auf die psychische Gesundheit
In den letzten Jahren wächst das internationale Interesse am Einfluss von Mikro- und Makronährstoffen auf den Gehirnstoffwechsel und damit das Auftreten und den Verlauf psychischer Erkrankungen. So wird einers...
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Multiple Chemikaliensensitivität (MCS)
Ein aktuelles Phänomen in der Umweltmedizin ist die multiple Chemikaliensensitivität (MCS). Betroffene berichten von einer subjektiven Unverträglichkeit kleinster Mengen ubiquitär vorhandener Chemikalien. Die ...
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20. Fortbildungskongress Davos — Vorträge
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Psychiatrische und somatische Morbidität bei Patienten mit vermuteter Multiple Chemical Sensitivity (MCS)