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  1. Article

    Open Access

    A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease

    Effective, disease-modifying therapeutics for the treatment of Alzheimer’s disease (AD) remain a large unmet need. Extensive evidence suggests that amyloid beta (Aβ) is central to AD pathophysiology, and Aβ ol...

    Christopher H. van Dyck, Adam P. Mecca, Ryan S. O’Dell… in Alzheimer's Research & Therapy (2024)

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  2. Article

    Open Access

    Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

    Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ plaque burden is not well-correlated with ...

    Ryan S. O’Dell, Adam P. Mecca, Ming-Kai Chen… in Alzheimer's Research & Therapy (2021)

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  3. No Access

    Chapter and Conference Paper

    Synthesizing Multi-tracer PET Images for Alzheimer’s Disease Patients Using a 3D Unified Anatomy-Aware Cyclic Adversarial Network

    Positron Emission Tomography (PET) is an important tool for studying Alzheimer’s disease (AD). PET scans can be used as diagnostics tools, and to provide molecular characterization of patients with cognitive d...

    Bo Zhou, Rui Wang, Ming-Kai Chen… in Medical Image Computing and Computer Assis… (2021)

  4. Article

    Open Access

    Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone

    The secreted ligand Reelin is believed to regulate the translocation of prospective layer 6 (L6) neocortical neurons into the preplate, a loose layer of pioneer neurons that overlies the ventricular zone. Rece...

    Ryan S O’Dell, Candida J M Ustine, David A Cameron, Sean M Lawless… in Neural Development (2012)

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