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  1. Article

    Down Syndrome B-Lymphocyte Subpopulations, Intrinsic Defect or Decreased T-Lymphocyte Help

    Down syndrome (DS) is known for increased incidence of respiratory infections and autoimmune diseases, indicating impaired immunity. Until now, attention has been mainly focused on T lymphocytes. Therefore, we...

    Ruud H J Verstegen, Maaike A A Kusters, Eugenie F A Gemen… in Pediatric Research (2010)

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  2. Article

    Both Normal Memory Counts and Decreased Naive Cells Favor Intrinsic Defect Over Early Senescence of Down Syndrome T Lymphocytes

    Because of their increased malignancies, autoimmune diseases, and infections, patients with Down syndrome (DS) show features of immunodeficiency. The DS thymus and T lymphocyte subsets have indeed proven to be...

    Maaike A A Kusters, Eugenie F A Gemen, Ruud H J Verstegen… in Pediatric Research (2010)

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  3. Article

    Open Access

    Increased rate of respiratory symptoms in children with Down syndrome: a 2-year web-based parent-reported prospective study

    To compare the incidence of respiratory symptoms and short-term consequences between children with Down syndrome and children from the general population, we conducted a prospective parent-reported observation...

    Noortje B. Eijsvoogel, Ruud H. J. Verstegen… in European Journal of Pediatrics (2022)

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    Article

    On-demand drug quantification: an increasing need in pediatric patients

    Ruud H. J. Verstegen, Benjamin Jung, Tamorah R. Lewis, Shinya Ito in Pediatric Research (2023)

  5. No Access

    Article

    Clinical Presentation and Diagnosis of Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) in Children: A Sco** Review

    Effective treatment of drug reactions with eosinophilia and systemic symptoms (DReSS) requires early diagnosis and close monitoring. Diagnosing DReSS is especially challenging in children due to a low incidenc...

    Frances St George-Hyslop, Nicole Cherepacha… in Clinical Reviews in Allergy & Immunology (2024)

  6. No Access

    Article

    Management and Long-Term Outcomes of Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) in Children: A Sco** Review

    Drug reaction with eosinophilia and systemic symptoms (DReSS) is known to cause mortality and long-term sequelae in the pediatric population, however there are no established clinical practice guidelines for t...

    Nicole Cherepacha, Frances St George-Hyslop… in American Journal of Clinical Dermatology (2024)