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  1. Article

    Open Access

    11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial

    Glucocorticoids prescribed to limit inflammation, have significant adverse effects. As 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active glucocorticoid, we investigated whether 11β-HSD1 inh...

    Nantia Othonos, Riccardo Pofi, Anastasia Arvaniti, Sarah White… in Nature Communications (2023)

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  2. Article

    Open Access

    Risk prediction models for incident type 2 diabetes in Chinese people with intermediate hyperglycemia: a systematic literature review and external validation study

    People with intermediate hyperglycemia (IH), including impaired fasting glucose and/or impaired glucose tolerance, are at higher risk of develo** type 2 diabetes (T2D) than those with normoglycemia. We aimed...

    Shishi Xu, Ruth L. Coleman, Qin Wan, Yeqing Gu, Ge Meng… in Cardiovascular Diabetology (2022)

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  3. Article

    Open Access

    Meta-analysis of the impact of alpha-glucosidase inhibitors on incident diabetes and cardiovascular outcomes

    Alpha-glucosidase inhibitors (AGIs) have been shown to reduce incident type 2 diabetes but their impact on cardiovascular (CV) disease remains controversial. We sought to identify the overall impact of AGIs wi...

    Ruth L. Coleman, Charles A. B. Scott, Zhihui Lang… in Cardiovascular Diabetology (2019)

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  4. No Access

    Article

    Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

    Ewan Pearson, Kathleen Giacomini and the Metformin Genetics Consortium perform a genome-wide association study for glycemic response to the antidiabetic drug metformin. They find an intronic allele of the GLUT...

    Kaixin Zhou, Sook Wah Yee, Eric L Seiser, Nienke van Leeuwen… in Nature Genetics (2016)