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  1. No Access

    Article

    Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer

    Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in GC targeted therapies has occurred. Synthetic lethality refers to the concept that simu...

    Haigang Geng, Ruolan Qian, Yiqing Zhong, **angyu Tang, **aojun Zhang… in Cancer Gene Therapy (2024)

  2. Article

    Open Access

    Multi-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer

    Numerous studies have used multi-region sampling approaches to characterize intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (HCC). However, conventional multi-region sampling strategies do not pres...

    Chen Yang, Senquan Zhang, Zhuoan Cheng, Zhicheng Liu, Linmeng Zhang… in Genome Medicine (2022)

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