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Article
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in GC targeted therapies has occurred. Synthetic lethality refers to the concept that simu...
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Article
Open AccessMulti-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer
Numerous studies have used multi-region sampling approaches to characterize intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (HCC). However, conventional multi-region sampling strategies do not pres...
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Article
Interactions between HMG proteins (HMG1/2 and HMG14/17) and human ε-globin gene promoter (ε-promoter)
High mobility group (HMG) proteins are abundant non-histone proteins in the nuclei of eukaryocytes. It has been shown that HMG proteins may play important roles in the structure and function of chromatin. In t...
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Article
Interactions between HMG proteins and the core sequence of DNaseI hypersensitive site 2 in the locus control region (LCR) of the human β-like globin gene cluster
HMG proteins are abundant chromosomal non-histone proteins. It has been suggested that the HMG proteins may play an important role in the structure and function of chromatin. In the present study, the binding ...
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Article
Interactions between GATA transcription factors and the DNaseI hypersensitive sites in the human β-globin gene LCR
In this study, we analyze the binding of nuclear proteins isolated from the hydroxyurea (Hu)-induced and uninduced HEL cells to the DNasel hypersensitive sites III (HS3-14991-14716 bp) and IV(HS4 -18586-18306 ...
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Article
CREB is activated in EPO induced HEL cells
cAMP response element binding protein (CREB) is a transcription factor in nucleus. The activating CREB can specifically bind to the cAMP response element (CRE). The present result showed that erythropoietin (E...
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Article
Interactions between the nuclear matrix proteins and the 5′-flankingcis-acting elements of the human ε-globin gene
An erythroid-specific nuclear matrix protein (termed ε-NMPk) in K562 cells, which can specifically bind to the positive stage-specific regulatory element (ε-PRE II, - 446 - 419 bp) upstream of the human ε-globin ...
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Article
HS3 of the mouse β-LCR
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Article
A stage-specific protein factor binding to a CACCC motif in both human β-globin gene promoter and 5'-HS2 region
The DNaseI hypersensitive site 2 (HS2) of human β- globin locus control region (LCR) is required for the high level expression of human β-globin genes. In the present study, a stage-specific protein factor (LPF-β
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Article
Identification of the development stage-specific factors in mouse fetal liver binding to the human β-globin gene promoter
In order to elucidate the molecular mechanisms of globin gene expression during embryonic development, the nuclear extracts from mouse hematopoietic tissue at different stages of development have been prepared...
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Article
Proteins binding to the 5′-flanking regulatory elements of the human β-globin gene
The binding of nuclear proteins prepared from mouse erythroid tissue in different developmental stages to the 5′-flanking regulatory elements of human β-globin gene, two negative control regions(NCR1, -610 to -49...
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Article
A DNA-binding protein factor in K562 nuclear extract interacts with positive control region (PCR) in the 5′-flanking sequence of human β-globin gene
It has been known that there are at least three regulatory regions (NCR1, NCR2 and PCR) in the 5′-flanking sequence (from −610 bp to +1 bp) of human β-globin gene and that the function of PCR is unique to the hum...
