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Article
Open AccessHistone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells
DNA repair promotes the progression and recurrence of glioblastoma (GBM). However, there remain no effective therapies for targeting the DNA damage response and repair (DDR) pathway in the clinical setting. Th...
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Article
Open AccessImproved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells
Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houp...
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Article
Open AccessParticipation of GATA-3 in regulation of bone healing through transcriptional upregulation of bcl-xL expression
We have previously demonstrated the expression of GATA-DNA-binding protein (GATA)-3, a transcription factor, in osteoblasts and have verified its function in transducing cell survival signaling. This translati...
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Article
Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-X L gene expression and protein translocation
Nitric oxide (NO) has biphasic effects on regulating osteoblast survival and death. This study was aimed to evaluate the effects of NO pretreatment on hydrogen peroxide (HP)-induced insults of rat osteoblasts ...
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Article
Open AccessHonokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction
Eliminating cancer stem cells (CSCs) has been suggested for prevention of tumor recurrence and metastasis. Honokiol, an active compound of Magnolia officinalis, had been proposed to be a potential candidate drug ...
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Article
Roles of microRNA-1 in hypoxia-induced apoptotic insults to neuronal cells
Hypoxia is a common occurrence in brain tumors and traumatic brain injury. microRNA (miR)-1 participates in the regulation of brain development and neuronal function. Interestingly, miR-1 can mediate ischemia-...
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Article
Effects of Polypropylene Carbonate/Poly(d,l-lactic) Acid/Tricalcium Phosphate Elastic Composites on Improving Osteoblast Maturation
Bone tissue engineering utilizing biomaterials to improve osteoblast growth has provided de novo consideration for therapy of bone diseases. Polypropylene carbonate (PPC) is a polymer with a low glass transition ...
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Article
MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells
MicroRNAs (miRNAs) can regulate cell survival and death by targeting apoptosis-related gene expression. miR-210 is one of the most hypoxia-sensitive miRNAs. In this study, we evaluated the roles of miR-210 in ...
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Article
Hyperventilation accelerates rise in arterial blood concentrations of sevoflurane in gynecologic patients
We investigated whether ventilation volumes affected arterial blood sevoflurane concentration (A sev) and its uptake into the body during general anesthesia.
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Article
Open AccessLipoteichoic acid induces surfactant protein-A biosynthesis in human alveolar type II epithelial cells through activating the MEK1/2-ERK1/2-NF-κB pathway
Lipoteichoic acid (LTA), a gram-positive bacterial outer membrane component, can cause septic shock. Our previous studies showed that the gram-negative endotoxin, lipopolysaccharide (LPS), could induce surfact...
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Article
Water ingestion reduces skin blood flow through sympathetic vasoconstriction
Water ingestion induces a pressor effect in patients with efferent baroreflex impairment and a mild pressor effect in elderly healthy subjects. However, water raised the total peripheral vascular resistance (T...
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Article
Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactive oxygen species-mediated activation of an intrinsic mitochondrion-dependent pathway
Alveolar type II epithelial cells can regulate immune responses to sepsis-induced acute lung injury. Lipopolysaccharide (LPS), an outer membrane component of Gram-negative bacteria, can cause septic shock. Thi...
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Article
The effect of heat-moisture exchanger and closed-circuit technique on airway climate during desflurane anesthesia
We assessed whether closed-circuit anesthesia (CCA) could provide a more favorable airway climate than semiclosed anesthesia (SCA), and we also determined the beneficial effect of heat moisture exchangers (HME...
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Article
Propofol reduces nitric oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible nitric oxide synthase
Nitric oxide is an active oxidant that contributes to the physiology and pathophysiology of macrophages. Propofol has been widely used in intravenous anesthesia. It possess antioxidant and immunomodulating eff...
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Article
Therapeutic concentrations of propofol protects mouse macrophages from nitric oxide-induced cell death and apoptosis
To evaluate the potential effect of a clinically relevant concentration of propofol (PPF) on cell viability and nitric oxide-induced macrophage apoptosis.
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Article
Induction of cytochrome P450 1A in hamster liver and lung by 6-nitrochrysene
The present study has determined the effect of 6-nitrochrysene (6-NC) on hepatic and pulmonary cytochrome P450 (P450)-dependent monooxygenases using hamsters pretreated with the nitrated polycyclic aromatic h...
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Article
Induction of cytochromes P450 1A, 2B and 2E in hamster tissues by acetone
The inductive effects of acetone on cytochromes P450 1A, 2B and 2E in liver, kidney and lung were studied using hamsters administered acetone in drinking water. Acetone administration caused five-, two- and s...
