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Chapter
Kreislauf
Der 58-jährige H.K. entwickelt im Laufe eines sehr stressigen Arbeitstages zunehmend Schmerzen hinter dem Brustbein, Unruhe, Aufgeregtheit, verschwommenes Sehen, Schwindel, Übelkeit und Atemnot. Der herbeigeru...
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Article
Inhibition of suicidal erythrocyte death by nitric oxide
Nitric oxide (NO) is known to counteract apoptosis by S-nitrosylation of protein thiol groups. NO is generated and stored in erythrocytes, which may undergo eryptosis, a suicidal cell death similar to apoptosi...
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Article
The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE−/− mice
In this study, we investigated the effects of prolonged administration of the selective COX-2 inhibitors celecoxib and rofecoxib and the non-selective NSAID naproxen on the initiation and progression of athero...
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Article
The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells
In the present study we determined whether the endothelium-derived hyperpolarizing factor (EDHF), in addition to its acute effects on vascular tone, activates intracellular signalling pathways other than thos...
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Article
Cytochrome P450 2C is an EDHF synthase in coronary arteries
In most arterial beds a significant endothelium-dependent dilation to various stimuli persists even after inhibition of nitric oxide synthase and cyclo-oxygenase. This dilator response is preceded by an endoth...
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Article
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular remodelling and angiogenesis1,2,3. Physi...
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Chapter
Vascular Effects of NO
Nitric oxide synthase (NOS) III is a constitutively expressed 135-kDa protein predominantly associated with the particulate subcellular fraction, suggesting that the native enzyme is a membrane-bound protein [...
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Article
Paracrine functions of the coronary vascular endothelium
Coronary vascular endothelial cells control vascular tone by modulating the local concentration of circulating vasoactive substances (e.g. adenine nucleotides, biogenic amines and bradykinin) and by synthesisi...
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Chapter
Paracrine functions of the coronary vascular endothelium
Coronary vascular endothelial cells control vascular tone by modulating the local concentration of circulating vasoactive substances (e.g. adenine nucleotides, biogenic amines and bradykinin) and by synthesisi...
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Article
Volatile and intravenous anesthetics selectively attenuate the release of endothelium-derived hyperpolarizing factor elicited by bradykinin in the coronary microcirculation
In addition to nitric oxide (NO) and prostacyclin (PGI2) another endothelium-derived factor, which hyperpolarizes vascular smooth muscle cell via activation of K+ channels, contributes to the vasorelaxant effect ...
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Article
Characterization of furoxans as a new class of tolerance-resistant nitrovasodilators
The vasodilator effects of C92-4609 (4-hydroxymethyl-furoxan-3-carboxamide, CAS 1609), C92-4678(4-phenyl-furoxan-3-carboxylic acid (pyridyl-3-yl-methyl)-amide), C92-4679 (3-phenyl-furoxan4-carboxylic acid (pyr...
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Chapter
Mechanisms of Shear Stress-Dependent Endothelial Nitric Oxide Release: Cardiovascular Implications
Endothelial cells produce a variety of factors involved in the control of vascular tone, platelet activation and cell growth, one of the most important being nitric oxide (NO). Although continuously produced i...
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Chapter
Regulation of Platelet Function by Flow-Induced Release of Endothelial Autacoids
Under normal conditions, the vascular endothelium significantly contributes to the control of cardiovascular homeostasis by maintaining platelets in an inactive resting state. In response to vessel wall damage...
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Article
Arterial size determines the enhancement of contractile responses after suppression of endothelium-derived relaxing factor formation
We studied the effect of endothelium-derived relaxing factor (EDRF) on norepinephrine-induced contractile responses and on the tissue guanosine-3′,5′-phosphate (cGMP) concentration of isolated rabbit arteries ...
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Article
Enzymic and nonenzymic release of NO accounts for the vasodilator activity of the metabolites of CAS 936, a novel long-acting sydnonimine derivative
The molecular mechanism(s) underlying the vasodilator activity of CAS 936 (3-(cis-2,6-dimethylpiperidino)-N-(4-methoxybenzoyl)-sydnonimine) and its metabolites 3-(cis-2,6-dimethylpiperidino)-sydnonimine (C87 3...
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Article
Elevated guanosine 3′:5′-cyclic monophosphate mediates the depression of nitrovasodilator reactivity in endothelium-intact blood vessels
The influence of endothelium-derived nitric oxide (EDNO) on relaxation induced by the nitrovasodilators, sodium nitroprusside and sodium nitrite was assessed in phenylephrine-stimulated hamster thoracic aortas...
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Article
Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting enzyme inhibitors in human endothelial cells
The effects of angiotensin-converting enzyme (ACE) inhibitors on intracellular calcium concentration ([Ca2+]i) were examined under resting conditions and after stimulation with bradykinin in cultured human umbili...
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Article
N G-nitro-l-arginine antagonizes endothelium-dependent dilator responses by inhibiting endothelium-derived relaxing factor release in the isolated rabbit heart
The effects of a recently described inhibitor of endothelial NO synthesis, N G-nitro-l-arginine (l-NNA), on the vasomotor responses to endothelium-dependent and independent vasodilators, and on the release of end...
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Article
Effects of the calmodulin antagonists fendiline and calmidazolium on aggregation, secretion of ATP, and internal calcium in washed human platelets
Ca2+-calmodulin dependent phosphorylation of myosin is essential for the induction of platelet shape change and subsequent reactions. Therefore, we studied the effects of the calmodulin antagonists fendiline and ...
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Article
Activators of potassium channels enhance calcium influx into endothelial cells as a consequence of potassium currents
Ca2+ influx into stimulated endothelial cells is attenuated by depolarization. We hypothesized that Ca2+ influx is driven by the membrane potential and may be enhanced by hyperpolarizing drugs like activators of ...
