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Article
Open AccessClinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito
Long-acting injectable medications, such as atovaquone, offer the prospect of a “chemical vaccine” for malaria, combining drug efficacy with vaccine durability. However, selection and transmission of drug-resi...
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Article
Open AccessMetabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors
Spiroindolone and pyrazoleamide antimalarial compounds target Plasmodium falciparum P-type ATPase (PfATP4) and induce disruption of intracellular Na+ homeostasis. Recently, a PfATP4 mutation was discovered that c...
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Article
Open AccessMetabolic adjustments of blood-stage Plasmodium falciparum in response to sublethal pyrazoleamide exposure
Due to the recurring loss of antimalarial drugs to resistance, there is a need for novel targets, drugs, and combination therapies to ensure the availability of current and future countermeasures. Pyrazoleamid...
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Article
Open AccessFunctional annotation of serine hydrolases in the asexual erythrocytic stage of Plasmodium falciparum
Enzymes of the serine hydrolase superfamily are ubiquitous, highly versatile catalysts that mediate a wide variety of metabolic reactions in eukaryotic cells, while also being amenable to selective inhibition....
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Article
Open AccessGenetic diversity of Plasmodium vivax in clinical isolates from Bangladesh
Plasmodium vivax is the second most prevalent human malaria parasite in Bangladesh; however, there are no data of its genetic diversity. Several molecular markers are available where P...
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Article
Open AccessRole of underappreciated vectors in malaria transmission in an endemic region of Bangladesh-India border
Despite the efforts of the National Malaria Control Programme, malaria remains as an important public health problem in Bangladesh, particularly in the south-eastern region bordering India. Successful malaria ...
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Article
Open AccessPerformance of a HRP-2/pLDH based rapid diagnostic test at the Bangladesh-India-Myanmar border areas for diagnosis of clinical malaria
The rapid diagnostic test (RDT) has been adopted in contemporary malaria control and management programmes around the world as it represents a fast and apt alternative for malaria diagnosis in a resource-limit...
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Article
Open AccessEvaluation of the OnSite (Pf/Pan) rapid diagnostic test for diagnosis of clinical malaria
Accurate diagnosis of malaria is an essential prerequisite for proper treatment and drug resistance monitoring. Microscopy is considered the gold standard for malaria diagnosis but has limitations. ELISA, PCR,...
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Article
Open AccessDiversity of anopheline species and their Plasmodium infection status in rural Bandarban, Bangladesh
Historically, the Chittagong Hill Tracts (CHT) of Bangladesh was considered hyperendemic for malaria. To better understand the contemporary malaria epidemiology and to develop new and innovative control strate...
