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  1. No Access

    Article

    Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

    The E3 ubiquitin ligases that modify the kinase RIP2 downstream of the receptor Nod2 remain unclear. Moynagh and colleagues show that Pellino3 ubiquitinates RIP2 for Nod2-induced activation of the transcriptio...

    Shuo Yang, Bingwei Wang, Fiachra Humphries, Ruaidhri Jackson… in Nature Immunology (2013)

  2. No Access

    Article

    Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons

    Signaling through toll-like receptors induces cytokines and type I interferon. Moynagh and colleagues show that the E3 ubiquitin ligase Pellino3 specifically represses the expression of type I interferon in re...

    Jakub Siednienko, Ruaidhri Jackson, Mark Mellett, Nezira Delagic… in Nature Immunology (2012)