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Article
Roles and regulation of tRNA-derived small RNAs in animals
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA degradation. These small RNAs have rece...
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Article
Mechanism of Efferocytosis in Determining Ischaemic Stroke Resolution—Diving into Microglia/Macrophage Functions and Therapeutic Modality
After ischaemic cerebral vascular injury, efferocytosis—a process known as the efficient clearance of apoptotic cells (ACs) by various phagocytes in both physiological and pathological states—is crucial for ma...
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Article
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner
TRMT1 is an N2-methylguanosine (m2G) and N2,N2-methylguanosine (m22G) methyltransferase that targets G26 of both cytoplasmic and mitochondrial tRNAs. In higher eukaryotes, most cytoplasmic tRNAs with G26 carry m2
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Article
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis
Naive T cells undergo radical changes during the transition from dormant to hyperactive states upon activation, which necessitates de novo protein production via transcription and translation. However, the mec...
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Article
The occurrence order and cross-talk of different tRNA modifications
Chemical modifications expand the composition of RNA molecules from four standard nucleosides to over 160 modified nucleosides, which greatly increase the complexity and utility of RNAs. Transfer RNAs (tRNAs) ...
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Article
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
Members of the mammalian AlkB family are known to mediate nucleic acid demethylation1,2. ALKBH7, a mammalian AlkB homologue, localizes in mitochondria and affects metabolism3, but its function and mechanism of ac...
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Article
5-HMF attenuates striatum oxidative damage via Nrf2/ARE signaling pathway following transient global cerebral ischemia
Recent studies have shown 5-hydroxymethyl-2-furfural (5-HMF) has favorable biological effects, and its neuroprotection in a variety of neurological diseases has been noted. Our previous study showed that treat...
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Article
The Impact of Multiparity on Uterine Gene Expression and Decidualization in Mice
It has been well established that a previous pregnancy exhibits a beneficial effect on the subsequent pregnancy. However, the underlying mechanisms have not been defined. We hypothesized that multiparity may a...
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Article
Rectification and phase locking of graphite
Rectification phenomena and the phase locking in a two-dimensional overdamped Frenkel–Kontorova model with a graphite periodic substrate were studied. The presence of dc and ac forces in the longitudinal direc...
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Article
Open AccessMesenchymal stem cells, not conditioned medium, contribute to kidney repair after ischemia-reperfusion injury
Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection o...
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Article
Progesterone Regulates Secretin Expression in Mouse Uterus During Early Pregnancy
Secretin, a classical gastrointestinal and neuroendocrine peptide, plays an important role in maintaining the body fluid balance. However, the expression and regulation of secretin in the reproductive system a...
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Article
Open AccessDiscovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl-tRNA synthetase (LeuRS) plays an...
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Article
Characterization of Interleukin-33 and Soluble ST2 in Serum and Their Association with Disease Severity in Patients with Chronic Kidney Disease
This study aims to test the serum levels of interleukin-33 (IL-33) and soluble ST2 (sST2) in patients with chronic kidney disease (CKD) and to evaluate their association with disease severity.
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Article
Treatment of 5/6 nephrectomy rats with sulodexide: a novel therapy for chronic renal failure
Sulodexide, a glycosaminoglycan, could reduce albuminuria in diabetic patients. The aim of this study was to determine whether sulodexide could be used to treat chronic kidney failure in rats.
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Article
Erratum to: Prenatal and Perinatal Risk Factors for Autism in China
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Article
Open AccessPrenatal and Perinatal Risk Factors for Autism in China
We conducted a case–control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education sc...
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Article
The anatomical basis and prevention of neurogenic voiding dysfunction following radical hysterectomy
The disorder of neurogenic dysfunction is one of the most important complications of radical hysterectomy. In order to prevent this potential complication, the authors have studied the composition and layers o...
