227 Result(s)
within
Ru-**a Zhao
English
-
Article
FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of public health concerns. The activation of FXR shows promise to co...
-
Article
Optical and electrical anisotropy regulation engineering of low-dimensional materials toward polarized detection and imaging applications
Polarized-sensitive image sensors are a kind of photodetector with great development potential due to their enhanced ability to detect and identify the target objects from the aspect of spatial, spectral and p...
-
Article
A supramolecular fluorescence sensor array for the differentiation of multiple anions and prediction of iodine in artificial urine using machine learning
The simultaneous discrimination and detection of multiple anions in an aqueous solution has been a major challenge due to their structural similarity and low charge radii. In this study, we have constructed a ...
-
Article
Synthesis, Crystal Structures, In Vitro Cytostatic Activity and DFT Studies of Four Organotin(IV) Complexes Derived From Schiff-Base Carboxylic Acid
Four triorganotin(IV) complexes, [(Ph3Sn)2L] (1), [(Et3Sn)2L]n (2), [(Me3Sn)2L] n (3), [(Me3Sn)3L(µ2-OH)] n (4) [H2L = 5-[(9-anthracenylmethylene)amino]-isophthalic acid], have been synthesized and characterized ...
-
Article
Open AccessFluoride impairs vascular smooth muscle A7R5 cell lines via disrupting amino acids metabolism
Given the insidious and high-fatality nature of cardiovascular diseases (CVDs), the emergence of fluoride as a newly identified risk factor demands serious consideration alongside traditional risk factors. Whi...
-
Article
Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations
Histone deacetylase inhibitors (HDACis) are important drugs for cancer therapy, but the indistinct resistant mechanisms of solid tumor therapy greatly limit their clinical application. In this study we conduct...
-
Article
Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair
Histone H3 Lys36 (H3K36) methylation and its associated modifiers are crucial for DNA double-strand break (DSB) repair, but the mechanism governing whether and how different H3K36 methylation forms impact repa...
-
Article
Hydroxylated hierarchical flower-like COF for solid-phase extraction of adrenergic receptor agonists in milk
A new detection platform based on a hydroxylated covalent organic framework (COF) integrated with liquid chromatography–tandem mass spectrometry (LC–MS/MS) was constructed and used for detecting adrenergic rec...
-
Article
Open AccessDifferences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 infections in neonates
Differences in clinical characteristics of early-onset and late-onset severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in neonates remain unclear. This study aimed to determine whether t...
-
Article
Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn
Matrix metalloproteinase 13 (MMP13) is an extracellular matrix protease that affects the progression of atherosclerotic plaques and arterial thrombi by degrading collagens, modifying protein structures and reg...
-
Article
Open AccessRapid development of double-hit mRNA antibody cocktail against orthopoxviruses
The Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV), remains a significant public health threat worldwide. The development of therapeutic antibodies against orthopoxviruses is largely...
-
Article
Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging
Aging-induced aortic stiffness has been associated with altered fatty acid metabolism. We studied aortic stiffness using cardiac magnetic resonance (CMR)-assessed ventriculo-arterial coupling (VAC) and novel a...
-
Article
KLK7, KLK10, and KLK11 in Papillary Thyroid Cancer: Bioinformatic Analysis and Experimental Validation
Despite many studies on papillary thyroid carcinoma (PTC) in the past few decades, some critical and significant genes remain undiscovered. To explore genes that may play crucial roles in PTC, a detailed anal...
-
Article
Open AccessLaser acupuncture and photobiomodulation therapy in Bell’s palsy with a duration of greater than 8 weeks: a randomized controlled trial
To investigate the efficacy of laser acupuncture and photobiomodulation therapy in alleviating symptoms among patients diagnosed with Bell’s palsy with duration of greater than 8 weeks. The randomized controll...
-
Article
Open AccessMetagenomic characterization of a novel non-ammonia-oxidizing Thaumarchaeota from hadal sediment
The hadal sediment, found at an ocean depth of more than 6000 m, is geographically isolated and under extremely high hydrostatic pressure, resulting in a unique ecosystem. Thaumarchaeota are ubiquitous marine ...
-
Article
Assessment of right ventricular diastolic function in pediatric patients with repaired tetralogy of Fallot by cardiovascular magnetic resonance and echocardiography
Cardiovascular magnetic resonance (CMR) imaging is routinely performed for assessing right ventricular (RV) systolic but not diastolic function. We aimed to investigate CMR-based assessment of RV diastolic fun...
-
Chapter and Conference Paper
Feasibility Analysis of Pickering Emulsion as Fracturing Fluid in Shale Gas Reservoir
Aiming at the problems of low proppant-carrying capacity and low fracture conductivity of slick water fracturing fluid, a novel fracturing fluid based on Pickering emulsion was fabricated, which was expected t...
-
Chapter and Conference Paper
Carbon Dioxide Flooding Feasibility of Well Groups in Ultra-deep High Temperature, High Pressure and High Salt Reservoirs - An Example from the Donghe 6 Block of Tarim Oilfield
The Donghe 6 block in Tarim oilfield has the problems of ultra-deep, high temperature, high pressure, high salinity, low permeability, strong water sensitivity, low oil production, low water cut and low recove...
-
Chapter and Conference Paper
Research on Attack-Defense Game Evolution of Aircraft Swarms Considering Weapon Operational Effectiveness
Aiming to the problem of attack and defence game between aircraft clusters, an aircraft cluster attack and defence game evolution model is established, and the influence of different weaponry on the decision-m...
-
Article
Open AccessGlucose fluctuations aggravate myocardial fibrosis via activating the CaMKII/Stat3 signaling in type 2 diabtetes
Glucose fluctuations (GF) are a risk factor for cardiovascular complications associated with type 2 diabetes. However, there is a lack of adequate research on the effect of GF on myocardial fibrosis and the un...
