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  1. No Access

    Article

    Human methylenetetrahydrofolate reductase: isolation of cDNA, map** and mutation identification

    Methylenetetrahydrofolate reductase (MTHFR) catalyses the reduction of methylenetetrahydrofolate to methyltetrahydrofolate, a cofactor for homocysteine methylation to methionine. MTHFR deficiency, an autosomal...

    Philippe Goyette, James S. Sumner, Renate Milos, Alessandra M.V. Duncan… in Nature Genetics (1994)

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    Chapter

    Cobalamin-Dependent and Cobalamin-Independent Methionine Synthases in Escherichia coli: Two Solutions to the Same Chemical Problem

    Two genes encoding proteins with methionine synthase activity are found in Escherichia coli. Both enzymes use methyltetrahydrofolate as a methyl donor to catalyze the conversion of homocysteine to methionine, as ...

    James T. Drummond, Rowena G. Matthews in Chemistry and Biology of Pteridines and Folates (1993)

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    Chapter

    The Role of Folylpolyglutamates in the Regulation of Folate Metabolism

    Folylpolyglutamates have been shown to function as potent inhibitors, relative to the corresponding monoglutamates, of two enzymes involves in the metabolism of methylenetetrahydrofolate (CH2-H4folate) in mammali...

    Rowena G. Matthews, Jonathan Ross, Charles M. Baugh… in Folyl and Antifolyl Polyglutamates (1983)