7 Result(s)
within
Ross Vlahos
Biomedicine
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Article
Cromakalim inhibits transmitter acetylcholine release in rat trachea by an action on epithelial cells and a diffusible factor
The present study was undertaken to investigate further the effects of the potassium channel opening drug cromakalim on the release of transmitter acetylcholine from cholinergic nerves of rat isolated trachea ...
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Article
Open AccessPreclinical animal models of COPD
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Protocol
Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice
Cigarette smoking is a major cause of chronic obstructive pulmonary disease (COPD). Inhalation of cigarette smoke causes inflammation of the airways, airway wall remodelling, mucus hypersecretion and progressi...
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Article
Open AccessIncreased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production
It is well established that lung pathology and inflammation are more severe during respiratory infections complicated by the presence of both bacteria and viruses. Whilst co-infection can result in invasive pn...
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Article
Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice
The present study investigated the efficacy of the hepatoprotective drug matrine (Mtr) for its new application for hepatosteatosis and associated disorders in glucose homeostasis. The study was performed in tw...
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Article
Open AccessEbselen prevents cigarette smoke-induced cognitive dysfunction in mice by preserving hippocampal synaptophysin expression
Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmonary inflammation into the systemic circulation may damage the brain, leading to cognitive ...
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Protocol
Assessing Lung Inflammation and Pathology in Preclinical Models of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is an incurable disease that is a major cause of mortality and morbidity worldwide. Cigarette smoking is a major cause of COPD and triggers progressive airflow limi...
