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Article
Open AccessEarly-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice
Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent airflow limitation can develop more aggressively. ...
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Protocol
Assessing Lung Inflammation and Pathology in Preclinical Models of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is an incurable disease that is a major cause of mortality and morbidity worldwide. Cigarette smoking is a major cause of COPD and triggers progressive airflow limi...
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Article
Open AccessEbselen prevents cigarette smoke-induced cognitive dysfunction in mice by preserving hippocampal synaptophysin expression
Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmonary inflammation into the systemic circulation may damage the brain, leading to cognitive ...
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Article
Open AccessBlocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models
Acute respiratory distress syndrome (ARDS) is triggered by various aetiological factors such as trauma, sepsis and respiratory viruses including SARS-CoV-2 and influenza A virus. Immune profiling of severe COV...
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Article
Open AccessCigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation
Cigarette smoking is a risk factor for stroke and is linked to stroke severity. Previous studies have shown that cigarette smoke extract (CSE) triggers endothelial dysfunction in vitro by initiating oxidative str...
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Article
Open AccessIschaemic stroke in mice induces lung inflammation but not acute lung injury
Stroke is a major cause of death worldwide and ischemic stroke is the most common subtype accounting for approximately 80% of all cases. Pulmonary complications occur in the first few days to weeks following i...
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Article
Open AccessIntranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice
Toll-like receptor 7 (TLR7) is a pattern recognition receptor that recognizes viral RNA following endocytosis of the virus and initiates a powerful immune response characterized by Type I IFN production and pr...
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Article
Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice
The present study investigated the efficacy of the hepatoprotective drug matrine (Mtr) for its new application for hepatosteatosis and associated disorders in glucose homeostasis. The study was performed in tw...
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Article
Open AccessIncreased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production
It is well established that lung pathology and inflammation are more severe during respiratory infections complicated by the presence of both bacteria and viruses. Whilst co-infection can result in invasive pn...
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Protocol
Protocols to Evaluate Cigarette Smoke-Induced Lung Inflammation and Pathology in Mice
Cigarette smoking is a major cause of chronic obstructive pulmonary disease (COPD). Inhalation of cigarette smoke causes inflammation of the airways, airway wall remodelling, mucus hypersecretion and progressi...
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Article
Open AccessEndosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes t...
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Chapter
Immunomodulatory Regulation of Lung Regeneration and Repair
To protect against the wide variety of microorganisms, dusts and pollutants that we continually inhale during respiration the lung is fortified by a network of mucosal innate immune cells. Innate immune cells ...
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Article
Open AccessPreclinical animal models of COPD
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Article
Open AccessUrokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
Urokinase-type plasminogen activator (u-PA) has been implicated in fibrinolysis, cell migration, latent cytokine activation, cell activation, T-cell activation, and tissue remodeling, all of which are involved...
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Article
Open AccessCigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice
Cigarette smoke has both pro-inflammatory and immunosuppressive effects. Both active and passive cigarette smoke exposure are linked to an increased incidence and severity of respiratory virus infections, but ...
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Article
Effect of Short-Term Cigarette Smoke Exposure on Body Weight, Appetite and Brain Neuropeptide Y in Mice
Although nicotinic receptors have been demonstrated in hypothalamic appetite-regulating areas and nicotine administration alters food intake and body weight in both animals and humans, the mechanisms underlyin...
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Article
Cromakalim inhibits transmitter acetylcholine release in rat trachea by an action on epithelial cells and a diffusible factor
The present study was undertaken to investigate further the effects of the potassium channel opening drug cromakalim on the release of transmitter acetylcholine from cholinergic nerves of rat isolated trachea ...
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Chapter
Airway smooth muscle cells
Airway smooth muscle (ASM) cell complexity is becoming increasingly apparent. Initially considered to be merely a contractile element, it is now known that smooth muscle cells actively regulate their function ...
