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Assessing Lung Inflammation and Pathology in Preclinical Models of Chronic Obstructive Pulmonary Disease

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  1. Article

    Open Access

    Ebselen prevents cigarette smoke-induced cognitive dysfunction in mice by preserving hippocampal synaptophysin expression

    Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” of pulmonary inflammation into the systemic circulation may damage the brain, leading to cognitive ...

    Simone N. De Luca, Kurt Brassington, Stanley M. H. Chan in Journal of Neuroinflammation (2022)

  2. Article

    Open Access

    Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production

    It is well established that lung pathology and inflammation are more severe during respiratory infections complicated by the presence of both bacteria and viruses. Whilst co-infection can result in invasive pn...

    Hao Wang, Melissa Blackall, Luba Sominsky, Sarah J. Spencer in Journal of Neuroinflammation (2018)

  3. Article

    Open Access

    Preclinical animal models of COPD

    Ross Vlahos in Journal of Inflammation (2013)