4 Result(s)
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Article
Open AccessThe therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma
Background. Uterine leiomyosarcoma is a rare aggressive smooth muscle cancer with poor survival rates. RNA Polymerase I (Pol I) activity is elevated in many cancers supporting tumour growth and prior studies in ...
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Article
Open AccessA novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction
Survival rates for pediatric patients suffering from mixed lineage leukemia (MLL)-rearranged leukemia remain below 50% and more targeted, less toxic therapies are urgently needed. A screening method optimized to ...
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Article
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest
When 3T6 cells are confluent, they withdraw from the cell cycle. Concomitant with cell cycle arrest a significant reduction in RNA polymerase I transcription (80% decrease at 100% confluence) is observed. In t...
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Regulation of Ribosomal DNA Transcription During Cardiomyocyte Hypertrophy
Cardiomyocyte hypertrophy, induced by norepinephrine, endothelin-I, and contraction, is associated with increased rates of protein synthesis and reexpression of genes associated with the fetal gene program. Th...
